Table 1 Clinical characteristics of the patients

Patients (n=)

129

103

-

45

45

-

50

50

-

Age (years)

Median-IQR

68

[58–76]

64

[50.5–76]

0.065

69

[58–76]

68

[48–78]

0.37

69

[59– 77]

67

[51– 81]

0.95

Mortality (n= %)

120 (92%)

54 (52%)

< 0.01

44 (97%)

27 (60%)

< 0.0001

50 (100%)

36 (72%)

< 0.0001

Sex F (n= %)

41 (41%)

45 (43%)

0.11

18 (40%)

15 (33%)

0.66

16 (32%)

23 (46%)

0.21

Smoking (n= %)

14 (11%)

21 (20%)

0.07

5 (11%)

10 (22%)

0.25

5 (10%)

9 (18%)

0.38

Obesity (n= %)

21 (16%)

22 (21%)

0.46

10 (22%)

9 (20%)

1

10 (20%)

10 (22%)

1

Hypothyroidism (n= %)

29 (23%)

15 (15%)

0.14

7 (15%)

10 (22%)

0.59

10 (20%)

7 (14%)

0.54

Diabetes (n= %)

33 (26%)

15 (14%)

0.046

12 (26%)

7 (15%)

0.3

14 (28%)

7 (14%)

0.14

High blood pressure (n= %)

51 (4%)

50 (48%)

0.27

15 (33%)

22 (48%)

0.19

18 (32%)

25 (50%)

0.25

Chronic heart disease (n= %)

29 (23%)

31 (30%)

0.28

4 (8.9%)

12 (26%)

0.053

19 (38%)

11 (22%)

0.12

Lung disease (n= %)

21 (16%)

17 (16%)

1

6 (13%)

8 (17%)

0.77

9 (18%)

7 (14%)

0.78

Burn (n= %)

0

1 (1.6%)

-

0

1 (2.2%)

-

0

1 (2%)

-

Chronic Renal Disease (n= %)

10 (9.0%)

10 (9.7)

0.59

3 (6.7)

8 (17%)

0.19

3 (6%)

5 (10%)

0.71

Chronic liver disease (n= %)

12 (10%)

11 (10%)

1

4 (8.9%)

5 (11%)

1

6 (12%)

6 (12%)

1

Neurological disease (n= %)

12 (9.5%)

19 (18%)

0.076

1 (2.2%)

9 (20%)

0.018

4 (8%)

9 (18%)

0.23

Chronic Immunosuppression (n= %)

21 (16%)

9 (8.7%)

0.11

8 (17%)

4 (8.9%)

0.35

8 (16%)

2 (4%)

0.095

Neoplasm (n= %)

12 (9%)

15 (14%)

0.33

5 (11%)

8 (17%)

0.54

6 (12%)

8 (16%)

0.77

Use of central venous catheter (n= %)

123 (98%)

90 (87%)

< 0.0001

45 (100%)

43 (95%)

0.54

50 (100%)

46 (92%)

0.12

Central venous catheter days

13. 7

[6.73–20.8]

5

[2.72–11]

< 0.0001

12.4 [8.09–15]

8.97

[6.04–14.2]

0.09

8.04 [4.34–11.8]

5.84

[3.01–11.5]

0.63

Central venous catheter isolation (n= %)

33 (26%)

13 (12%)

0.012

9 (20%)

7 (15%)

0.78

5 (10%)

4 (10%)

1

ITS (n= %)

30 (23%)

8 (7.9%)

< 0.0001

9 (20%)

4 (8.9%)

0.23

5 (10%)

1 (2%)

0.2

Use of urinary catheter (n= %)

120 (95%)

86 (83%)

< 0.0001

43 (95%)

41 (91%)

0.67

50 (100%)

45 (90%)

0.06

Days with urinary catheter

14.6

[7.49–21.0]

5

[2.72–11]

< 0.0001

12.4 [8.10–15.4]

9

[6.08–13]

0.044

8.04 [4.50–11.8]

5.60

[3.16–11.5]

0.44

Urinary catheter isolation (n= %)

29 (23%)

6 (5.8%)

< 0.0001

8 (17%)

4 (8.9%)

0.35

6 (12%)

3 (6%)

0.48

ISTU AC (n= %)

19 (15%)

2 (1.9%)

0.0013

6 (13%)

1 (2.2%)

0.11

4 (8%)

1 (2%)

0.35

Use of intubation or tracheostomy (n= %)

118 (93%)

77 (74%)

< 0.0001

42 (93%)

37 (82%)

0.19

50 (100%)

50 (100%)

-

Días con intubación o traqueostomía

14.5

[7–21.0]

4

[2.33–9.20]

< 0.0001

11.0 [7.18–14.7]

8

[5.27–11.1]

0.014

6.91 [4.08–10.5]

5

[2.96–9.61]

0.12

Isolations in intubation or tracheostomy (n= %)

56 (44%)

10 (9.8%)

< 0.0001

21 (43%)

9 (20%)

0.013

14 (28%)

6 (12%)

0.08

VAP (n= %)

48 (36%)

8 (7.8%)

< 0.0001

18 (40%)

7 (15%)

0.018

13 (26%)

4 (8%)

0.03

gram-positive infection (n= %)

46 (36%)

8 (7.8%)

< 0.0001

11 (24%)

4 (8.9%)

0.089

7 (14%)

3 (6%)

0.31

gram-negative infection (n= %)

41 (32%)

10 (9.7%)

< 0.0001

10 (22%)

8 (17%)

0.79

8 (16%)

3 (6%)

0.2

Atypical Infection (n= %)

8 (6.3%)

2 (1.9%)

0.19

6 (13%)

2 (4.4%)

0.26

0

3 (6%)

0.24

Fungal Infection (n= %)

13 (10%)

2 (1.9%)

0.022

5 (11%)

1 (2.2%)

0.20

0

3 (6%)

0.24