Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population

BMC Infectious Diseases

Table 3 Risk allele frequency of MMP9 gene SNPs in the case-control data set of children with severe pneumonia

CHR	BP	SNP	Major allele	Minor allele	Minor Allele Frequency in Cases	Minor Allele Frequency in Controls	Test	OR (95% CI)	P
20	44638781	rs3918251	G	A	0.265	0.302	Allelic	0.832 (0.748–0.925)	0.0006
							Heterozygous	0.867 (0.755–0.996)	0.0442
							Homozygous	0.651 (0.496–0.854)	0.0019
20	44642406	rs2250889	C	G	0.191	0.220	Allelic	0.843 (0.744–0.938)	0.0023
							Heterozygous	0.841 (0.730–0.969)	0.0165
							Homozygous	0.698 (0.496–0.983)	0.0392
20	44643770	rs3918262	A	G	0.453	0.418	Allelic	1.156 (1.052–1.269)	0.0024
							Heterozygous	1.019 (0.877–1.184)	0.8066
							Homozygous	1.374 (1.143–1.652)	0.0007
20	44643111	rs17577	G	A	0.114	0.132	Allelic	0.835 (0.731–0.973)	0.0198
							Heterozygous	0.782 (0.664–0.921)	0.0032
							Homozygous	1.082 (0.666–1.759)	0.7496
20	44640391	rs3918254	C	T	0.218	0.198	Allelic	1.135 (1.014–1.271)	0.0279
							Heterozygous	1.068 (0.927–1.232)	0.3619
							Homozygous	1.474 (1.091–1.991)	0.0114
20	44645153	rs9509	T	C	0.232	0.219	Allelic	1.082 (0.970–1.207)	0.1588
							Heterozygous	1.016 (0.883–1.168)	0.8280
							Homozygous	1.326 (1.001–1.756)	0.0491

P value adjusted by gender and age. The P-values were corrected by Bonferroni’s method with a threshold of 0.0042. Calculation of the OR was also based on the minor allele of each SNP
Abbreviations: CHR Chromosome, BP Base pair (where the SNP is located), SNP Single-nucleotide polymorphism, OR Odds ratio, CI Confidence interval

ISSN: 1471-2334