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Table 3 Bivariate analysis of clinical characteristics, treatment, and evolution of patients with COVID-19 in the Adult Intensive Care Unit of the Hospital de ClĆ­nicas between August 2020 and August 2021. San Lorenzo. Paraguay (nā€‰=ā€‰214)

From: Clinical evolution and mortality of critically ill patients with SARS-CoV-2 pneumonia treated with remdesivir in an adult intensive care unit of Paraguay

Variable

Deceased (nā€‰=ā€‰82)

Survivors (nā€‰=ā€‰132)

p-value

Ageā€‰>ā€‰60

40 (48.8)

39 (29.5)

0.005

Male sex

51 (62.2)

73 (55.3)

0.321

Obesity

40 (48.8)

62 (47.0)

0.797

Diabetes mellitus

29 (35.4)

27 (20.5)

0.016

Cardiac disease

8 (9.8)

4 (3.0)

0.076

Hypertension

46 (56.1)

61 (46.2)

0.160

Chronic renal failure

9 (11)

3 (2.3)

0.007

APACHE IIā€‰>ā€‰20

22 (26.8)

6 (4.5)

<ā€‰0.001

Renal injury

31/68 (45.6)

33/121 (27.3)

0.011

Hepatic injury

9/39 (23.1)

5/65 (7.7)

0.026

Remdesivir

29 (35.4)

80 (60.6)

<ā€‰0.001

Received remdesivir until the 8th

day of illness

13 (26.0)

42 (32.1)

<ā€‰0.001

Received remdesivir after the 8th day of illness

15 (18.5)

37 (28.2)

Ā 

No remdesivir

53 (65.4)

52 (39.7)

Ā 

Plasma

18 (22.0)

30 (22.7)

0.895

Tocilizumab

5 (6.1)

15 (11.4)

0.198

MV

81 (98.8)

54 (40.9)

<ā€‰0.001

ARDS

46 (56.8)

66 (50.0)

0.335

Norepinephrine

80 (97.6)

44 (33.3)

<ā€‰0.001

Hemodialysis

22 (26.8)

2 (1.5)

<ā€‰0.001

Intercurrent infections

69 (84.1)

96 (72.7)

0.053

  1. APACHE II: Acute Physiology and Chronic Health Evaluation, MV: Mechanical ventilation, ARDS: Acute Respiratory Distress Syndrome