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Table 2 Relationship between drugs and outcomes of patients’

From: Long-term oral ACEI/ARB therapy is associated with disease severity in elderly COVID-19 omicron BA.2 patients with hypertension

Variables

Propensity Score Weighting

(Model 1)

Propensity Score Matching

(Model 2)

Multivariable Regression

(Model 3)

Non-ACEI group

(N = 763)

ACEI group

(N = 760)

OR/β(95%CI)

P value

Non-ACEI group

(N = 282)

ACEI group

(N = 282)

OR/β(95%CI)

P value

OR/β(95%CI)

P value

Exacerbation

101(13.23)

75(9.88)

0.64(0.46–0.89) a

0.0082

32(11.35)

19(6.74)

0.56(0.31–1.02)a

0.0589

0.33(0.18–0.63) a

0.0008

All-cause death

32(4.24)

16(2.12)

0.49(0.27–0.89) a

0.0201

9(3.19)

4(1.42)

0.44(0.13–1.43)a

0.1719

0.25(0.07–0.87) a

0.0294

Mechanical ventilation

61(8.01)

34(4.53)

0.54(0.35–0.82) a

0.0046

18(6.38)

8(2.84)

0.43(0.18-1.00)a

0.0505

0.29(0.11–0.76) a

0.0117

Respiratory failure

70(9.18)

34(4.53)

0.46(0.30–0.70) a

0.0003

20(7.09)

8(2.84)

0.38(0.17–0.88)a

0.0245

0.19(0.07–0.51) a

0.0010

Nucleic acid conversion time (NCT), days

14.00(10.00–19.00)

13.00(9.00–17.00)

-1.23(-2.21 - -0.26) b

0.0132

14.00(10.00–19.00)

13.00(9.00–17.00)

-1.33(-2.44 - -0.21)b

0.0199

-0.91(-1.86-0.04) b

0.0619

Total hospitalization costs, dollars

1458.21(991.93-2376.11)

1335.90(912.84-2109.78)

-124.16(-476.19–227.86) b

0.4889

1333.01(968.67-2268.39)

1254.68(873.69-1886.94)

-204.07(-554.91–146.76)b

0.2537

-169.66(-412.67-73.34) b

0.1716

  1. a Odds ratios; b β value