Table 2 Baseline Predictors of Paradoxical TB-IRIS in 384Â TB-HIV-Coinfected Patients Starting ART - Univariate Analysis
Parameter (numbers/percentage) | Total | TB-IRIS | Non-TB-IRIS | P |
|---|---|---|---|---|
n = 384 | n = 72 | n = 312 | ||
Age | Â | Â | Â | 0.003 |
 ≤ 40 years | 106(27.6%) | 30(41.7%) | 76(24.4%) |  |
 IQR | 32(27, 34) | 34(29, 36) | 31(26, 34) |  |
 ≥ 40 years | 278(72.4%) | 42(58.3%) | 236(75.6%) |  |
 IQR | 55(49, 63) | 55(49, 60) | 56(49, 64) |  |
Male | 325(84.6%) | 61(84.7%) | 264(84.6%) | 0.982 |
PTB disease | Â | Â | Â | Â |
 Smear positive | 238(62.0%) | 48(66.7%) | 190(60.9%) | 0.363 |
 Culture positive | 261(68.9%) | 56(80%) | 205(66.3%) | 0.055 |
 Molecular testing | 104(27.2%) | 22(26.3%) | 82(26.3%) | 0.462 |
Miliary | 61(15.9%) | 17(23.6%) | 44(14.1%) | 0.047 |
Extra-pulmonary tuberculosis | Â | Â | Â | Â |
 Tuberculous pleurisy | 68(17.7%) | 15(20.8%) | 53(17.0%) | 0.441 |
 Tuberculous lymphadenitis | 52(13.5%) | 12(16.7%) | 40(12.8%) | 0.390 |
 Tuberculous meningitis | 41(10.7%) | 10(13.9%) | 31(9.9%) | 0.382 |
 Intestinal TB | 24(6.3%) | 7(9.7%) | 17(5.4%) | 0.177 |
HB (≤ 90 g/L) | 132(34.4%) | 33(45.8%) | 99(31.7%) | 0.023 |
ALB (≤ 30 g/L) | 134(34.9%) | 25(34.7%) | 109(34.9%) | 0.973 |
Initial CD4+T-cell counts (≤ 50cells/µL ) | 188(49.0%) | 47(65.3%) | 141(45.2%) | 0.002 |
Initial HIV VL (≥ 500,000 copies/mL) | 194(50.5%) | 47(65.3%) | 147(47.1%) | 0.005 |
Time between ATT and ART initiation (days) | 16(13, 21) | 15(12,21) | 16(13, 21) | 0.495 |
HAART regimen | Â | Â | Â | 0.431 |
 INSTI- based | 176 | 36(20.5%) | 140(79.5%) |  |
 Non- INSTI- based | 208 | 36(17.3%) | 172(82.7%) |  |