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Table 2 Effect of S. Boulardii plus standard triple therapy vs. standard triple therapy on adverse events

From: The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials

Adverse events

Number of studies

Sample size

RR (95%CI)

Peffect

I2(%)

Pheterogeneity

Total adverse events

6

583

0.32 (0.21–0.48)

<0.00001

0

0.96

Diarrhea

13

2 059

0.46 (0.37–0.56)

<0.00001

14

0.31

Nausea

11

1 764

0.53 (0.40–0.72)

<0.0001

30

0.16

Vomiting

6

1 257

0.67 (0.47–0.94)

0.02

58

0.04

Constipation

6

1 099

0.42 (0.31–0.58)

<0.00001

0

0.83

Abdominal pain

6

1 319

0.67 (0.46–0.96)

0.03

43

0.12

Abdominal distention

4

408

0.47 (0.27–0.81)

0.006

0

0.53

Epigastric discomfort

2

198

0.41 (0.18–0.90)

0.03

0

0.50

Poor appetite

6

706

0.50 (0.35–0.72)

0.0002

13

0.33

Taste disorder

1

82

0.50 (0.16–1.53)

0.22

-

-

Stomatitis

2

740

0.26 (0.15–0.47)

<0.00001

0

0.80

Rash

4

382

0.32 (0.09–1.18)

0.09

0

0.97

  1. RR, relative risk; CI, confidence interval.