Adverse events | Number of studies | Sample size | RR (95%CI) | Peffect | I2(%) | Pheterogeneity |
---|---|---|---|---|---|---|
Total adverse events | 6 | 583 | 0.32 (0.21–0.48) | <0.00001 | 0 | 0.96 |
Diarrhea | 13 | 2 059 | 0.46 (0.37–0.56) | <0.00001 | 14 | 0.31 |
Nausea | 11 | 1 764 | 0.53 (0.40–0.72) | <0.0001 | 30 | 0.16 |
Vomiting | 6 | 1 257 | 0.67 (0.47–0.94) | 0.02 | 58 | 0.04 |
Constipation | 6 | 1 099 | 0.42 (0.31–0.58) | <0.00001 | 0 | 0.83 |
Abdominal pain | 6 | 1 319 | 0.67 (0.46–0.96) | 0.03 | 43 | 0.12 |
Abdominal distention | 4 | 408 | 0.47 (0.27–0.81) | 0.006 | 0 | 0.53 |
Epigastric discomfort | 2 | 198 | 0.41 (0.18–0.90) | 0.03 | 0 | 0.50 |
Poor appetite | 6 | 706 | 0.50 (0.35–0.72) | 0.0002 | 13 | 0.33 |
Taste disorder | 1 | 82 | 0.50 (0.16–1.53) | 0.22 | - | - |
Stomatitis | 2 | 740 | 0.26 (0.15–0.47) | <0.00001 | 0 | 0.80 |
Rash | 4 | 382 | 0.32 (0.09–1.18) | 0.09 | 0 | 0.97 |