Table 3 Outcomes according to intervention in studies included in the meta-analysis
Author | Drug | Dosage | Duration (days) | Number of cases | Average TOD (hours) | Clinical failure (2-3 days) | Clinical failure (5 days) | Mortality (%) | Adverse drug effect |
|---|---|---|---|---|---|---|---|---|---|
Varghese 2023 [18] | IV Doxy | 200 mg BD on D1 f/b 100 mg BD | 7 | 265 | 96* | 33/254 (13%) | 8/243 (3%) | 29 (10.9%) | 0b |
IV Azithro | 500 mg BD on D1 f/b 500 mg OD | 7 | 263 | 96* | 35/251 (14%) | 16/225 (7%) | 32 (12.2%) | 0b | |
Guan-Xiu-Gang 2022 [19] | IV Doxy | 100 mg BD | 7 | 701 | 48* | NA | NA | 30 (4.3%) | NA |
IV Azithro | 500 mg OD | 6 | 79 | 48* | NA | NA | 4 (5.1%) | NA | |
Hwang 2022 [20] | Oral Doxy | 100 mg BD | 8 | 217 | 72* | 66/108 (61%) | NA | 0 (0%) | NA |
IV Azithro | 500 mg OD | 4 | 109 | 72* | 64/109 (59%) | NA | 1 (0.9%) | NA | |
Kabir 2022 [21] | Oral Doxy | 2.2 mg/kg BD | 5 | 58 | 25.8 | 2 (4%) | NA | NA | 5 (9%) |
Oral Azithro | 10 mg/kg OD | 5 | 56 | 24.5 | 1 (2%) | NA | NA | 1 (2%) | |
Arun Babu 2021 [22] | Oral Doxy | 2.2 mg/kg BD | 7 | 344 | 44.6 | 49 (14%) | NA | NA | NA |
Oral Azithro | 10 mg/kg OD | 7 | 316 | 49.9 | 76 (24%) | NA | NA | NA | |
Barnabas 2021 [23] | Oral Doxy | NA | 7 | 46 | 30.5 | 11 (24%) | NA | 1 (2.2%) | NA |
Oral Azithro | NA | 7 | 57 | 38.5 | 20 (35%) | NA | 6 (10.5%) | NA | |
Veerappan 2021 [24] | Oral Doxy | 2.2 mg/kg BD | NA | 76 | 12* | 6 (8%) | NA | NA | NA |
Oral Azithro | 10 mg/kg OD | NA | 62 | 24* | 16 (26%) | NA | NA | NA | |
Chanta 2015 [25] | Oral Doxy or chloramphenicol | d-2.2 mg /kg BD, c-25mg/kg QID | 5 | 28 (d-9, c-19) | 30* | 4(14%) | NA | NA | 0 (0%) |
Oral Azithro | 20 mg/kg on D1 f/b 10 mg/kg | 3 | 29 | 36* | 5 (17%) | NA | NA | 1 (3%) | |
Phimda 2007 [26] | Oral Doxy | 200 mg stat f/b 100 mg BD | 7 | 27 | 48* | 11 (41%) | 0 (0%) | 0 (0%) | 27.6%a |
Oral Azithro | 1g stat f/b 500 mg OD | 3 | 30 | 60* | 21 (70%) | 1 (3%) | 0 (0%) | 10.6%a | |
Kim 2004 [27] | Oral Doxy | 100 mg BD | 7 | 46 | 29* | 13 (28%) | 3 (7%) | 0 (0%) | 16 (35%) |
Oral Azithro | 500 mg stat | 1 | 47 | 21* | 7 (15%) | 0 (0%) | 0 (0%) | 13 (28%) |