Table 1 Comparative studies for time to defervescence or mortality on doxycycline vs. azithromycin for scrub typhus
Sn | Author | Year of Study | Country | Type of Study | Age group | Eschar | Serology | Sample size | Severe scrub typhus |
|---|---|---|---|---|---|---|---|---|---|
1 | Varghese 2023 [18] | 2018-2022 | India | Randomised controlled trial | Adult (>15 years) | Yes | RDT | 528 | 528 (100%) |
2 | Guan-Xiu-Gang 2022 [19] | 2012-2018 | China | Retrospective cohort study | Adult and Paediatric | NA | Weil Felix test or IFA | 780 | 780 (100%) |
3 | Hwang 2022 [20] | 2013-2021 | South Korea | Retrospective cohort study | Adult (>18 years) | NA | IFA | 326 | 165 (51%) |
4 | Kabir 2022 [21] | 2019-2021 | India | Randomised controlled trial | Paediatric (<15 years) | Yes | Weil Felix test or ELISA | 114 | 0 |
5 | Arun Babu 2021 [22] | 2015-2019 | India | Prospective cohort study | Paediatric (<12 years) | NA | ELISA | 660 | 203 (31%) |
6 | Barnabas 2021 [23] | 2013-2015 | India | Prospective cohort study | Adult (≥15 years) | NA | ELISA | 103 | 103 (100%) |
7 | Veerappan 2021 [24] | 2017-2020 | India | Retrospective cohort study | Paediatric (<14 years) | NA | Rapid test | 138 | 22 (16%) |
8 | Chanta 2015 [25] | 2010-2013 | Thailand | Randomised controlled trial | Paediatric (<15 years) | Yes | Rapid test | 57 | 0 |
9 | Phimda 2007 [26] | 2003-2005 | Thailand | Randomised controlled trial | Adult (>14 years) | NA | IFA | 57 | 0 |
10 | Kim 2004 [27] | 2002-2003 | South Korea | Randomised controlled trial | Adult (>18 years) | NA | IFA | 93 | 0 |