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Table 4 Baseline data and primary endpoints of patients before and after propensity score weighting (n = 78)

From: Clinical application of vancomycin TDM in ventilated patients with gastrointestinal cancer: a propensity-matched analysis

 

Entire cohort

Propensity score weighting

Characteristics

Delayed group

Early group

χ2

p

Delayed group

Early group

χ2

p

(n = 55)

(n = 23)

  

(n = 23)

(n = 23)

  

Age, years

 Mean ± S.D

62.65 ± 11.87

68.78 ± 10.45

 

0.035*

65.22 ± 10.76

68.78 ± 10.45

 

0.260

 Median [range]

65 [56–70]

68 [61–76]

  

67 [60–74]

68 [61–76]

  

Sex, n(%)

   

0.542

   

0.381

 Male

42 (76.4%)

19 (82.6%)

  

21 (91.3%)

19 (82.6%)

  

 Female

13 (23.6%)

4 (17.4)

  

2 (8.7%)

4 (17.4)

  

Body weight, kg

 Mean ± S.D

75.53 ± 12.38

81.61 ± 9.302

 

0.038*

78.52 ± 11.63

81.61 ± 9.30

 

0.326

 Median [range]

77 [69–83]

84 [75–88]

  

80 [72–87]

84 [75–88]

  

Apache II score on ICU

 Mean ± S.D

19.51 ± 2.73

19.65 ± 3.60

 

0.849

20.00 ± 2.73

19.65 ± 3.60

 

0.714

 Median [range]

19 [18–22]

20 [17–22]

  

20 [17–22]

20 [17–22]

  

SOFA score

 Mean ± S.D

13.15 ± 2.41

13.17 ± 1.87

 

0.974

13.70 ± 2.55

13.17 ± 1.87

 

0.307

 Median [range]

13 [11–15]

13 [12–14]

  

13 [12–15]

13 [12–14]

  

Albumin (g/L)

 Mean ± S.D

27.86 ± 5.50

28.10 ± 6.53

 

0.867

27.24 ± 3.70

28.10 ± 6.53

 

0.587

 Median [range]

28.0 [25.7–32.3]

29.4 [23.7–33.5]

  

27.7 [25.7–29.4]

29.4 [23.7–33.5]

  

Serum creatinine (μmol/L)

 Mean ± S.D

62.73 ± 29.81

79.00 ± 26.24

 

0.026*

81.09 ± 32.46

79.00 ± 26.24

 

0.812

 Median [range]

50 [42–77]

76 [63–89]

  

74 [53–105]

76 [63–89]

  

Cys-C (mg/L)

 Mean ± S.D

1.11 ± 0.64

1.66 ± 0.56

 

0.001*

1.30 ± 0.48

1.67 ± 0.56

 

0.019*

 Median [range]

0.90 [0.74–1.24]

1.60 [1.25–1.90]

  

1.21 [0.98–1.56]

1.60 [1.25–1.90]

  

Primary endpoints

 Clinical success rate, n(%)

39 (70.9)

19 (82.6)

1.164

0.281

16 (69.6)

19 (82.6)

1.075

0.300

 28-day all-cause mortality,n(%)

4

0

0.585

0.444

3 (13.0)

1 (4.3)

0.274

0.601

 Composite outcome of new-onset AKI or RRT, n(%)

4 (7.3)

3 (13.0)

0.143

0.705

4 (17.4)

3 (13.0)

0.000

1.000

  1. Abbreviations: APACHE II acute physiology and chronic health evaluation II, SOFA Sequential Organ Failure Assessment, AKI acute kidney injury, RRT renal replacement therapy
  2. Note: Values for categorical variables are given as count (percentage); values for continuous variables, as mean ± standard deviation or median [interquartile range]
  3. *p < 0.05