Fig. 1

Significant loss of cross-reactive neutralizing capacity against VOC among children 6 months after primary infection. Analysis of WT, alpha, delta and omicron NAbs titers via pseudovirus neutralization propagation-incompetent VSV*DG (firefly luciferase) pseudovirus system bearing SARS-CoV-2 S-protein (wildtype, alpha, delta or omicron) in the envelope among pediatric subjects.A) WT-, alpha-, delta- and omicron-NAb.B) NAb subanalysis of the pediatric subjects according to age a) ≤10 years old (n = 17) and b)11–18 years old (n = 15). Scatterplots show line at median. Unpaired data were compared with Mann-Whitney-test. P < 0.05 was considered significant, only significant p values are documented in the figures