Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study

BMC Infectious Diseases

Table 3 The impact of gut microbiota on influenza pneumonias outcomes

Exposure	Method	N_IV	b	p	OR	Egger_intercept	P_pleiotropy
class Clostridia	IVW	12	-0.097	0.007	0.91	0.008	0.243
class Clostridia	MR Egger	12	-0.209	0.057	0.81	0.008	0.243
class Clostridia	WM	12	-0.120	0.012	0.89	0.008	0.243
family Defluviitaleaceae	IVW	11	-0.100	0.009	0.90	-0.003	0.840
family Defluviitaleaceae	MR Egger	11	-0.073	0.609	0.93	-0.003	0.840
family Defluviitaleaceae	WM	11	-0.095	0.023	0.91	-0.003	0.840
genus Anaerotruncus	IVW	13	0.093	0.022	1.10	-0.004	0.654
genus Anaerotruncus	MR Egger	13	0.146	0.258	1.16	-0.004	0.654
genus Anaerotruncus	WM	13	0.079	0.130	1.08	-0.004	0.654
genus Barnesiella	IVW	12	0.083	0.017	1.09	-0.001	0.895
genus Barnesiella	MR Egger	12	0.102	0.492	1.11	-0.001	0.895
genus Barnesiella	WM	12	0.101	0.031	1.11	-0.001	0.895
genus Oscillibacter	IVW	13	0.071	0.019	1.07	-0.010	0.357
genus Oscillibacter	MR Egger	13	0.178	0.152	1.19	-0.010	0.357
genus Oscillibacter	WM	13	0.045	0.220	1.05	-0.010	0.357
order Clostridiales	IVW	13	-0.077	0.028	0.93	0.009	0.213
order Clostridiales	MR Egger	13	-0.195	0.066	0.82	0.009	0.213
order Clostridiales	WM	13	-0.112	0.019	0.89	0.009	0.213
phylum Cyanobacteria	IVW	8	0.070	0.028	1.07	-0.014	0.325
phylum Cyanobacteria	MR Egger	8	0.186	0.149	1.20	-0.014	0.325
phylum Cyanobacteria	WM	8	0.079	0.065	1.08	-0.014	0.325

Abbreviations: b represents effect size, IVW refers to inverse variance weighted, MR denotes Mendelian randomization, WM stands for Weighted median, N_IV represents the number of instrumental variables, and OR stands for odds ratio

ISSN: 1471-2334