Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study

BMC Infectious Diseases

Table 2 The impact of influenza (not-pneumonias) on gut microbiota outcomes

Outcome	Method	N_IV	b	p	OR	Egger_intercept	P_pleiotropy
class Bacilli	IVW	6	0.182	0.000	1.20	-0.016	0.783
class Bacilli	MR Egger	6	0.286	0.469	1.33	-0.016	0.783
class Bacilli	WM	6	0.157	0.011	1.17	-0.016	0.783
family Lachnospiraceae	IVW	6	0.110	0.016	1.12	-0.026	0.681
family Lachnospiraceae	MR Egger	6	0.274	0.506	1.32	-0.026	0.681
family Lachnospiraceae	WM	6	0.141	0.019	1.15	-0.026	0.681
family Streptococcaceae	IVW	6	0.171	0.001	1.19	-0.058	0.390
family Streptococcaceae	MR Egger	6	0.544	0.236	1.72	-0.058	0.390
family Streptococcaceae	WM	6	0.133	0.052	1.14	-0.058	0.390
genus Anaerostipes	IVW	6	0.133	0.005	1.14	0.005	0.937
genus Anaerostipes	MR Egger	6	0.103	0.794	1.11	0.005	0.937
genus Anaerostipes	WM	6	0.131	0.037	1.14	0.005	0.937
genus Anaerotruncus	IVW	6	-0.165	0.001	0.85	0.008	0.910
genus Anaerotruncus	MR Egger	6	-0.216	0.642	0.81	0.008	0.910
genus Anaerotruncus	WM	6	-0.090	0.187	0.91	0.008	0.910
genus Streptococcus	IVW	6	0.161	0.006	1.18	-0.071	0.366
genus Streptococcus	MR Egger	6	0.615	0.242	1.85	-0.071	0.366
genus Streptococcus	WM	6	0.110	0.120	1.12	-0.071	0.366
order Lactobacillales	IVW	6	0.175	0.000	1.19	-0.013	0.822
order Lactobacillales	MR Egger	6	0.261	0.508	1.30	-0.013	0.822
order Lactobacillales	WM	6	0.153	0.015	1.17	-0.013	0.822

Abbreviations: b represents effect size, IVW refers to inverse variance weighted, MR denotes Mendelian randomization, WM stands for Weighted median, N_IV represents the number of instrumental variables, and OR stands for odds ratio

ISSN: 1471-2334