Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study

BMC Infectious Diseases

Table 1 The impact of gut microbiota on influenza (not-pneumonias) outcomes

Exposure	Method	N_IV	b	p	OR	Egger_intercept	P_pleiotropy
class Actinobacteria	IVW	14	-0.213	0.028	0.81	-0.008	0.678
class Actinobacteria	MR Egger	14	-0.104	0.711	0.90	-0.008	0.678
class Actinobacteria	WM	14	-0.178	0.189	0.84	-0.008	0.678
class Clostridia	IVW	12	-0.260	0.039	0.77	0.018	0.487
class Clostridia	MR Egger	12	-0.494	0.186	0.61	0.018	0.487
class Clostridia	WM	12	-0.141	0.376	0.87	0.018	0.487
genus Romboutsia	IVW	13	0.240	0.021	1.27	-0.029	0.270
genus Romboutsia	MR Egger	13	0.567	0.085	1.76	-0.029	0.270
genus Romboutsia	WM	13	0.251	0.075	1.29	-0.029	0.270
genus Streptococcus	IVW	12	-0.253	0.035	0.78	0.044	0.245
genus Streptococcus	MR Egger	12	-0.222	0.161	0.46	0.044	0.245
genus Streptococcus	WM	12	-0.253	0.035	0.80	0.044	0.245
genus Tyzzerella3	IVW	12	0.156	0.023	1.17	-0.012	0.835
genus Tyzzerella3	MR Egger	12	0.236	0.550	1.27	-0.012	0.835
genus Tyzzerella3	WM	12	0.158	0.072	1.17	-0.012	0.835

Abbreviations: b represents effect size, IVW refers to inverse variance weighted, MR denotes Mendelian randomization, WM stands for Weighted median, N_IV represents the number of instrumental variables, and OR stands for odds ratio

ISSN: 1471-2334