Table 3 Estimated causal effects of metabolites on sepsis/UTI by the multivariable Mendelian randomization analysis
Metabolite | Infections | Nsnp | Multivariable MR | |
|---|---|---|---|---|
OR (95% CI) | P | |||
1-stearoylglycerol | Sepsis | 228 | 0.561 (0.403–0.780) | 5.859E-04 |
3-carboxy-4-methyl-5-propyl-2-furanpropanoate | Sepsis | 228 | 0.780 (0.689–0.883) | 9.070E-05 |
X-12407 | Sepsis | 228 | 1.294 (1.131–1.481) | 1.745E-04 |
X-12847 | Sepsis | 228 | 1.344 (1.152–1.568) | 1.706E-04 |
Phenylacetate | UTI | 54 | 1.426 (1.152–1.765) | 1.098E-03 |
Cysteine | UTI | 54 | 1.522 (1.170–1.980) | 1.743E-03 |