Table 2 Sensitivity analysis for the causal association between blood metabolites and infection phenotypes

Glycerol

Sepsis

Lipid

17.248 (1.44%)

0.438

0.013

0.172

0.043

TRUE

8.267E-108

1-stearoylglycerol

Sepsis

Lipid

22.401 (0.00%)

0.555

0.014

0.154

0.039

TRUE

3.133E-155

3-carboxy-4-methyl-5-propyl-2-furanpropanoate

Sepsis

Lipid

6.795 (0.00%)

0.871

0.014

0.314

0.033

TRUE

2.379E-98

Dihomo-linoleate (20:2n6)

Sepsis

Fatty acid

7.125 (1.76%)

0.416

0.014

0.520

0.013

TRUE

8.532E-49

X-12407

Sepsis

Unknown metabolite

1.697 (0.00%)

0.989

0.002

0.893

0.047

TRUE

2.597E-93

X-12847

Sepsis

Unknown metabolite

10.864 (17.16%)

0.285

0.009

0.539

0.019

TRUE

3.728E-79

Ursodeoxycholate

Pneumonia

Lipid

9.275 (0.00%)

0.506

0.001

0.890

0.049

TRUE

1.300E-92

Kynurenine

Pneumonia

Amino acid

30.277 (0.00%)

0.651

0.001

0.861

0.004

TRUE

2.497E-263

X-14588

Pneumonia

Unknown metabolite

3.226 (0.00%)

0.919

0.002

0.834

0.042

TRUE

3.242E-69

Tryptophan

URTI

Amino acid

158.647 (5.45%)

0.299

0.018

0.117

0.013

TRUE

0.000E+00

Histidine

URTI

Amino acid

1.301 (0.00%)

0.935

0.003

0.910

0.032

TRUE

3.502E-53

Serotonin (5HT)

URTI

Amino acid

13.247 (0.00%)

0.507

0.009

0.633

0.021

TRUE

5.679E-86

Cysteine

UTI

Amino acid

13.757 (0.00%)

0.684

0.007

0.222

0.005

TRUE

8.899E-120

Phenylacetate

UTI

Amino acid

8.667 (19.23%)

0.277

0.002

0.836

0.033

TRUE

5.894E-58

Eicosenoate (20:1n9 or 11)

UTI

Fatty acid

11.253 (2.25%)

0.422

0.001

0.947

0.018

TRUE

4.033E-76

X-11483

UTI

Unknown metabolite

12.323 (18.85%)

0.264

0.002

0.756

0.027

TRUE

3.474E-122

X-11491

UTI

Unknown metabolite

6.888 (0.00%)

0.908

0.004

0.553

0.005

TRUE

3.973E-129