Fatty liver is associated with significant liver inflammation and increases the burden of advanced fibrosis in chronic HBV infection

Table 9 Subgroup analysis based on metabolic factors

Subgroups	NAFLD or not	Total	Significant liver inflammation (%)	P value	Significant liver fibrosis (%)	P value	Advanced liver fibrosis (%)	P value
Subgroup 1	Non-NAFLD	368	166 (45.109)	0.069	212 (57.609)	0.623	59 (16.033)	1.000
Subgroup 1	NAFLD	41	25 (60.976)	0.069	22 (53.659)	0.623	6 (14.634)	1.000
Subgroup 2	Non-NAFLD	377	170 (45.093)	0.035	218 (57.825)	0.871	62 (16.446)	0.670
Subgroup 2	NAFLD	43	27 (62.791)	0.035	24 (55.814)	0.871	8 (18.605)	0.670

NAFLD: Non-alcoholic fatty liver disease; Subgroup 1: individuals with T2DM, hypertension and overweight were excluded; Subgroup 2: only lean HBV-infected subjects were included

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