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Table 7 Factors associated with advanced liver fibrosis

From: Fatty liver is associated with significant liver inflammation and increases the burden of advanced fibrosis in chronic HBV infection

Variables

Univariate

Multivariate

P value

β ± SE

Wald

OR (95% CI)

P value

Age

0.067

    

Gender (if male)

0.036

0.644 ± 0.232

7.720

1.904 (1.209–2.998)

0.005

HBV DNA (Log10 IU/mL)

0.001

-0.139 ± 0.038

13.350

0.871 (0.808–0.938)

< 0.001

HbeAg (+)

0.099

    

BMI

0.465

    

Hypertension

0.560

    

T2DM

0.576

    

WBC

0.554

    

PLT

< 0.001

-0.010 ± 0.002

24.919

0.990 (0.987–0.994)

< 0.001

ALB

0.903

    

GLB

< 0.001

0.105 ± 0.024

19.018

1.111 (1.059–1.164)

< 0.001

Tbil

0.338

    

ALT

0.031

-0.011 ± 0.005

5.384

0.989 (0.980–0.998)

0.020

AST

0.007

0.023 ± 0.008

7.211

1.023 (1.006–1.040)

0.007

GGT

0.005

0.010 ± 0.003

9.924

1.010 (1.004–1.016)

0.002

ALP

0.533

    

Steatosis

0.229

    
  1. HBV: Hepatitis B virus; HbeAg: hepatitis B e antigen; BMI: Body mass index; T2DM: Type 2 diabetes mellitus; WBC: White blood cell count; PLT: Platelet; ALB: Albumin; GLB: Globulin; Tbil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate transferase; GGT: Gamma-glutamyltransferase; ALP: Alkaline phosphatase
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BMC Infectious Diseases

ISSN: 1471-2334

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