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Table 4 Histologic characteristics of HBV-infected patients with and without hepatic steatosis after PSM

From: Fatty liver is associated with significant liver inflammation and increases the burden of advanced fibrosis in chronic HBV infection

 

HBV infection (N = 254)

HBV infection + NAFLD (N = 254)

P value

Steatosis

  

< 0.001

0

254 (100%)

0

1

0

218 (85.83%)

2

0

33 (12.99%)

3

0

3 (1.18%)

Lobular inflammation

  

< 0.001

0

1 (0.39%)

0

1

193 (75.98%)

150 (59.06%)

2

59 (23.23%)

92 (36.22%)

3

1 (0.39%)

12 (4.72%)

4

0

0

Portal inflammation

  

< 0.001

1

165 (64.96%)

100 (39.37%)

2

81 (31.89%)

127 (50.00%)

3

8 (3.15%)

26 (10.24%)

4

0

1 (0.39%)

Hepatic ballooning

  

0.001

0

253 (99.61%)

238 (93.70%)

1

1 (0.39%)

9 (3.54%)

2

0

7 (2.76%)

3

0

0

G

  

< 0.001

1

148 (58.27%)

92 (36.22%)

2

98 (38.58%)

134 (52.76%)

3

8 (3.15%)

27 (10.63%)

4

0

1 (0.39%)

S

  

0.010

0

9 (3.54%)

0

1

105 (41.34%)

97 (38.19%)

2

100 (39.37%)

97 (38.19%)

3

20 (7.87%)

29 (11.42%)

4

20 (7.87%)

31 (12.20%)

Significant liver fibrosis

140 (55.12%)

157 (61.81%)

0.126

Advanced liver fibrosis

40 (15.75%)

60 (23.62%)

0.034

Significant liver inflammation

106 (41.73%)

162 (63.78%)

< 0.001

  1. PSM: Propensity score-matching; NAFLD: Non-alcoholic fatty liver disease; G: inflammation grade; S: fibrosis stage