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Table 2 Histologic characteristics of HBV-infected patients with and without hepatic steatosis

From: Fatty liver is associated with significant liver inflammation and increases the burden of advanced fibrosis in chronic HBV infection

 

HBV infection (N = 616)

HBV infection + NAFLD (N = 255)

P value

Steatosis

  

< 0.001

0

616 (100%)

0

1

0

219 (85.88%)

2

0

33 (12.94%)

3

0

3 (1.18%)

Lobular inflammation

  

0.323

0

1 (0.16%)

0

1

389 (63.15%)

150 (58.82%)

2

210 (34.09%)

93 (36.47%)

3

15 (2.44%)

12 (4.71%)

4

1 (0.16%)

0

Portal inflammation

  

< 0.001

1

360 (58.44%)

101 (39.61%)

2

227 (36.85%)

127 (49.80%)

3

26 (4.22%)

26 (10.20%)

4

3 (0.49%)

1 (0.39%)

Hepatic ballooning

   

0

608 (98.70%)

239 (93.73%)

 

1

8 (1.30%)

9 (3.53%)

< 0.001

2

0

7 (2.75%)

 

3

0

0

 

G

  

< 0.001

1

318 (51.62%)

92 (36.08%)

2

268 (43.51%)

135 (52.94%)

3

28 (4.55%)

27 (10.59%)

4

2 (0.32%)

1 (0.39%)

S

  

0.071

0

11 (1.79%)

0

1

236 (38.31%)

97 (38.04%)

2

259 (42.05%)

97 (38.04%)

3

54 (8.77%)

30 (11.76%)

4

56 (9.09%)

31 (12.16%)

Significant liver fibrosis

369 (59.90%)

158 (61.96%)

0.572

Advanced liver fibrosis

110 (17.857%)

61 (23.922%)

0.049

Significant liver inflammation

298 (48.38%)

163 (63.92%)

< 0.001

  1. NAFLD: Non-alcoholic fatty liver disease; G: inflammation grade; S: fibrosis stage