Clinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China

Table 6 Main Diagnosis and treatment of the nND

	Final main diagnosis	Antibiotic therapy before mNGS results	Antibiotic therapy after mNGS results	Outcome
Patient N	BSI (Escherichia coli), UTI (Enterococcus faecium)	Piperacillin tazobactam → Cefoperazone sulbactam → Imipenem cilastatin → Meropenem → Amikacin, Tigecycline → Ceftazidime → Meropenem	Meropenem, linezolid	Relieved
Patient M	Pulmonary aspergillosis	Piperacillin tazobactam	Voriconazole	Relieved
Patient O	Pulmonary tuberculosis	Ceftriaxone → Piperacillin tazobactam	Isonicotinic acid hydrazide, rifampicin, ethambutol, pyrazinamide, moxifloxacin	Relieved
Patient P^a	Multiple Myeloma	Valaciclovir → Valaciclovir, piperacillin tazobactam	No change	Relieved
Patient Q	Pulmonary tuberculosis	Piperacillin tazobactam	^b	Against-advice discharged
Patient R	Non-cystic fibrosis bronchiectasis	Piperacillin tazobactam	No change	Relieved
Patient S	Severe pneumonia^c, non-small cell lung cancer with metastases	Meropenem, moxifloxacin, Voriconazole, oseltamivir	Meropenem, acyclovir, voriconazole → Piperacillin tazobactam, acyclovir, sulfamethoxazole → Piperacillin tazobactam, caspofungin, sulfamethoxazole → Caspofungin, sulfamethoxazole	Relieved

ISSN: 1471-2334