Clinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China

Liang, Yingjian; Lin, Minmin; Qiu, Lidi; Chen, Meizhu; Tan, Cuiyan; Tu, Changli; Zheng, Xiaobin; Liu, Jing

doi:10.1186/s12879-023-08615-z

Table 5 Treatment of the patients diagnosed as ND

From: Clinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China

	Main diagnosis at admission	Diagnosis after mNGS	Antibiotic therapy before mNGS results	Antibiotic therapy after mNGS results	Outcome
Patient A	Pneumonia, Kidney Transplantation Recipient Combined BK Nephropathy	Pulmonary Nocardiosis, Lung Infection of Klebsiella pneumoniae, Kidney Transplantation Recipient Combined BK Nephropathy	Piperacillin tazobactam, → Voriconazole	Ceftriaxone, linezolid → Linezolid, faropenem	Relieved
Patient B	Pneumonia, Intracranial mass lesion	Pulmonary Nocardiosis, Cerebral Nocardiosis, Gastrointestinal Hemorrhage	Ceftriaxone	Ceftriaxone, meropenem, sulfamethoxazole → Imipenem cilastatin, ceftriaxone, sulfamethoxazole → Meropenem, amikacin, sulfamethoxazole	Relieved
Patient C^a	Nasopharyngeal carcinoma	NPC, Mixed Pulmonary Infections of Nocardia accompanied by other bacteria	Piperacillin tazobactam → Voriconazole	Amikacin, ceftriaxone, sulfamethoxazole, voriconazole → Amoxicillin and clavulanate potassium, sulfamethoxazole → Sulfamethoxazole	Against-advice discharged
Patient D	Pulmonary tuberculosis	Nontuberculosis mycobacteria infection, Pulmonary Nocardiosis	Isonicotinic acid hydrazide, rifampicin, ethambutol, pyrazinamide, clarithromycin	Rifampicin, levofloxacin, sulfamethoxazole, clarithromycin, amikacin	Relieved
Patient E	Non-cystic fibrosis bronchiectasis	Pulmonary Nocardiosis	Cefoperazone sulbactam	Sulfamethoxazole → Minocycline^c	Relieved
Patient F	Pulmonary tuberculosis	Pulmonary Nocardiosis, Non-cystic fibrosis bronchiectasis	Ceftriaxone	Ceftriaxone, sulfamethoxazole	Relieved
Patient G	Fever origin unknown	Pulmonary Nocardiosis	Ceftriaxone, isonicotinic acid hydrazide, rifampicin, ethambutol, pyrazinamide	Amoxicillin and Clavulanate Potassium, sulfamethoxazole, minocycline	Relieved
Patient H^b	Severe pneumonia	Severe pneumonia, Pulmonary Nocardiosis, Type 1 Respiratory Failure	Piperacillin tazobactam, moxifloxacin	No change	Against-advice discharged
Patient I^a	Hepatoma	Pulmonary Nocardiosis, Hepatoma	-	Ceftriaxone, sulfamethoxazole, amikacin	Relieved
Patient J	Pulmonary tuberculosis	Pulmonary Nocardiosis	Ceftriaxone	Sulfamethoxazole	Relieved
Patient K	Non-cystic fibrosis bronchiectasis, COPD, SSTI of left foot	Pulmonary Nocardiosis, SSTI of left foot, Non-cystic fibrosis bronchiectasis, COPD	Levofloxacin, fluconazole, cefoperazone sulbactam	Linezolid → Imipenem cilastatin, sulfamethoxazole → Sulfamethoxazole	Relieved
Patient L	Non-cystic fibrosis bronchiectasis	Pulmonary Nocardiosis	Piperacillin tazobactam	Sulfamethoxazole	Relieved

SSTI Skin soft tissue infection, COPD Chronic obstructive pulmonary disease
^aLung lesions finding before tumor treatment
^bDischarge against medical advice before mNGS results
^cAllergic to Sulfamethoxazole

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ISSN: 1471-2334

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