Table 2 CDKN2B-AS1 (rs1333049) and ZFHX3 (rs2106261) gene polymorphisms of COVID-19 patients and healthy controls
Severe COVID-19 cases (n = 90) | Moderate COVID-19 cases (n = 90) | Healthy controls (n = 180) | χ2 | p | ||||
|---|---|---|---|---|---|---|---|---|
No. | % | No. | % | No. | % | |||
CDKN2B-AS1 (rs1333049) | ||||||||
G/G | 12 | 13.3 | 18 | 20.0 | 88 | 48.9 | 49.106* | < 0.001* |
G/C | 64 | 71.1 | 48 | 53.3 | 68 | 37.8 | ||
C/C | 14 | 15.6 | 24 | 26.7 | 24 | 13.3 | ||
HWχ2 (p) | 16.098(< 0.001*) | 0.459(0.498) | 3.286(0.070) | |||||
Allele | ||||||||
G | 88 | 48.9 | 84 | 46.7 | 244 | 67.78 | 29.696* | < 0.001* |
C | 92 | 51.1 | 96 | 53.3 | 116 | 32.22 | ||
ZFHX3 (rs2106261) | ||||||||
C/C | 56 | 62.2 | 66 | 73.3 | 128 | 71.1 | 5.3884 | MCp = 0.253 |
C/T | 34 | 37.8 | 24 | 26.7 | 50 | 27.8 | ||
T/T | 0 | 0.0 | 0 | 0.0 | 2 | 1.1 | ||
HWχ2 (p0) | 4.881(0.027*) | 2.130(0.144) | 1.436(0.231) | |||||
Allele | ||||||||
C | 146 | 81.1 | 156 | 86.7 | 306 | 85.0 | 2.2838 | 0.319 |
T | 34 | 18.9 | 24 | 13.3 | 54 | 15.0 | ||