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Table 4 Base substitutions and resulting amino acid changes in six predicted virulence-associated loci of Greek B. melitensis strains, relative to the reference strain B. melitensis 16 M. Loci designation, base numbers, and amino acid numbers refer to the reference genome. Cluster denomination according to cgMLST results

From: Genotype diversity of brucellosis agents isolated from humans and animals in Greece based on whole-genome sequencing

  

ure

bspB

prpA

vceC

Cluster/ strain

 

BME_

RS03220

BME_

RS03225

BME_

RS03230

BME_

RS06340

BME_

RS01255

BME_

RS04715

MST11

Subst.

G270C

-

-

-

C222A

-

Effect

silent

   

stop codon

 

MST7

Subst.

G270C

-

-

-

-

-

Effect

silent

     

MST4

Subst.

-

-

-

C281T

-

-

Effect

   

Gly94Asp

  

MST10

Subst.

C1110T

-

-

-

-

-

Effect

Met370Ile

     

MST9

Subst.

-

-

C25T

-

del: 452–582

-

Effect

  

Asp9Asn

 

truncated

 

Bm-GRC-B9h

Subst.

-

G228A

-

-

-

G417C

Effect

 

silent

   

Lys139Asn