Prevalence of gram-negative bacteria and their antibiotic resistance in neonatal sepsis in Iran: a systematic review and meta-analysis

Moftian, Nazila; Rezaei-hachesu, Peyman; Arab-Zozani, Morteza; Samad-soltani, Taha; Esfandiari, Atefeh; Tabib, Mohammad Saleh; Mirnia, Kayvan

doi:10.1186/s12879-023-08508-1

Table 3 Subgroup analysis for the prevalence of Gram-negative bacteria in neonates with sepsis in Iran

From: Prevalence of gram-negative bacteria and their antibiotic resistance in neonatal sepsis in Iran: a systematic review and meta-analysis

	Bacteria	Studies (n)	Heterogeneity		95%CI	Pooled prevalence (%)	Model
	Bacteria	Studies (n)	I²	P-Value	95%CI	Pooled prevalence (%)	Model
Region
Center	K.pneumoniae	10	95.312	< 0.001	0.161–0.356	0.246	Random
	E.Coli	6	95.825	< 0.001	0.050–0.173	0.095	Random
	Entrobacter	9	87.132	< 0.001	0.046–0.135	0.079	Random
	P.aeruginosa^a	7	95.784	< 0.001	0.079–0.239	0.141	Random
	Acinobacter	1	0.000	1.000	0.065–0.101	0.081	Fixed
Overall			96.343	< 0.001	0.07–0.212	0.125	Random
East	K.pneumoniae	4	65.161	0.006	0.083–0.314	0.170	Random
	E.Coli	4	92.931	0.035	0.180–0.501	0.320	Random
	Entrobacter	2	0.000	0.482	0.122–0.193	0.155	Fixed
	P.aeruginosa	1	0.000	1.000	0.010–0.048	0.022	Fixed
	Acinobacter	2	0.000	0.962	0.032–0.083	0.052	Fixed
Overall			91.786	0.006	0.045–0.259	0.114	Random
North	K.pneumoniae	4	90.337	< 0.001	0.0.77–0.539	0.238	Random
	E.Coli	3	91.255	0.001	0.211–0.905	0.344	Random
	Entrobacter	2	65.645	0.054	0.026–0.371	0.110	Random
	P.aeruginosa	2	0.000	0.691	0.012–0.107	0.036	Fixed
	Acinobacter	1	0.000	1.000	0.007–0.282	0.050	Fixed
Overall			90.673	< 0.001	0.045–0.447	0.163	Random
Northwest	K.pneumoniae	5	57.237	0.053	0.102–0.280	0.174	Random
	E.Coli	4	71.373	0.015	0.029–0.121	0.060	Random
	Entrobacter	3	76.726	0.014	0.034–0.163	0.076	Random
	P.aeruginosa	4	54.984	0.083	0.015–0.072	0.033	Random
	Acinobacter	3	94.131	< 0.001	0.021–0.125	0.053	Random
Overall			85.396	< 0.001	0.035–0.136	0.070	Random
South	K.pneumoniae	3	89.000	< 0.001	0.018–0.606	0143	Random
	E.Coli	3	95.260	< 0.001	0.046–0.772	0.288	Random
	Entrobacter	3	96.371	< 0.001	0.019–0.647	0.160	Random
	P.aeruginosa	2	87.867	0.004	0.012–0.794	0.179	Random
	Acinobacter	3	97.163	< 0.001	0.028–0.725	0.215	Random
Overall			93.786	< 0.001	0.079–0.406	0.195	Random
West	K.pneumoniae	4	93.781	< 0.001	0.075–0.422	0.196	Random
	E.Coli	5	93.812	< 0.001	0.081–0.397	0.194	Random
	Entrobacter	4	75.476	0.003	0.058–0.325	0.147	Random
	P.aeruginosa	2	0.000	0.617	0.032–0.091	0.054	Fixed
	Acinobacter	3	90.238	< 0.001	0.031–0.319	0.109	Random
Overall			91.756	< 0.001	0.079–0.239	0.141	Random
Hospital type
Maternity 's hospital	K.pneumoniae	21	88.401	< 0.001	0.154–0.337	0.203	Random
	E.Coli	20	92.033	< 0.001	0.206–0.288	0.233	Random
	Entrobacter	17	90.020	< 0.001	0.083–0.223	0.139	Random
	P.aeruginosa	13	94.679	< 0.001	0.054–0.189	0.100	Random
	Acinobacter	11	93.967	< 0.001	0.053–0.283	0.117	Random
Overall			91.696	< 0.001	0.104–0.210	0.149	Random
Children’s hospital	K.pneumoniae	9	95.709	< 0.001	0.118–0.332	0.205	Random
	E.Coli	5	96.987	< 0.001	0.030–0.155	0.070	Random
	Entrobacter	7	96.897	< 0.001	0.059–0.217	0.116	Random
	P.aeruginosa	5	87.844	< 0.001	0.026–0.142	0.062	Random
	Acinobacter	2	87.741	0.004	0.011–0.157	0.043	Random
Overall			96.976	< 0.001	0.049–0.173	0.094	Random

^aPseudomonas aeruginosa

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