Fig. 7

Boxplots with overlaid strip plots showing the distribution of the data for the metabolites significantly altered in the following comparisons: HIV-/TB + /Tn- (TB) versus HIV + /TB + /Tn- (untreated HIV/TB) and HIV + /TB + /Tn- (untreated HIV/TB) versus HIV + /TB + /Tn + (ART-treated HIV/TB). (A) Metabolites significantly altered by HIV infection during an existing TB infection, of which this trend was reversed to some extent by ART (although not with statistical significance in all cases). (B) 3-Hydroxyisovaleric acid was the only metabolite not significantly altered by HIV infection in those with untreated HIV/TB co-infection but was significantly altered because of ART in co-infected individuals