Fig. 3

Box plots with overlaid strip plots showing the distribution of the data for the metabolites significantly altered in the t-tests comparing the HCD (n = 5) and LCD (n = 4) groups within the untreated HIV/TB co-infected group before exclusion of samples with high CD4 T-cell counts. Analysis of the role of CD4 in the treated co-infected group was not done due to the large heterogeneity displayed by this group. These results were not statistically significant after multiple testing, but as this is an explorative study, p-values before correction are reported here: (A) 0.032, (B) 0.037, (C) 0.038, and (D) 0.041