Overall cohort | Propensity matching cohort | |||||
---|---|---|---|---|---|---|
FUBC ( n = 564) | No FUBC (n = 248 ) | P value | FUBC ( n = 236) | No FUBC (n = 236 ) | P Value | |
Age, median (IQR) | 64 (54–75) | 65 (55–77) | 0.395 | 64 (51–75) | 65 (53.5–76) | 0.385 |
Male sex, n (%) | 319 (56.6) | 139 (56) | 0.892 | 130 (55.1) | 131 (55.5) | 0.926 |
Comorbidities, n (%) | ||||||
Diabetes mellitus | 163 (28.9) | 74 (29.8) | 0.787 | 54 (22.9) | 71 (30.1) | 0.076 |
Hypertension | 234 (41.5) | 96 (38.7) | 0.458 | 96 (40.7) | 94 (39.8) | 0.851 |
Chronic renal Failure | 86 (15.2) | 38 (15.3) | 0.978 | 33 (14.0) | 35 (14.8) | 0.793 |
Coronary artery disease | 119 (21.1) | 47 (19) | 0.485 | 50 (21.2) | 44 (18.6) | 0.489 |
Cardiac failure | 57 (10.) | 24 (9.7) | 0.851 | 19 (8.1) | 22 (9.3 | 0.624 |
Cerebrovascular disease | 66 (11.7) | 30 (12.1) | 0.873 | 31 (13.1) | 29 (12.3) | 0.782 |
Chronic pulmonary disease | 58 (10.3) | 26 (10.5) | 0.931 | 24 (10.2) | 26 (11.0) | 0.765 |
Malignancy | 264 (46.8) | 120 (48.4) | 0.678 | 128 (54.2) | 116 (49.2) | 0.269 |
CCI(n), median (IQR) | 5 (3–7) | 5 (3–7) | 0.250 | 5 (3–7) | 5 (3–7) | 0.481 |
Clinical severity at index blood culture time, median(IQR) | ||||||
SOFA | 4 (2–6) | 4 (2–7) | 0.011 | 4 (2–7) | 4 (2–7) | 0.994 |
SIRS | 2 (1–3) | 2 (1–3) | 0.161 | 2 (1–3) | 2 (1–3) | 0.509 |
Admission ward, n (%) | ||||||
ICU | 229 (40.6) | 128 (51.6) | 0.004 | 111(47.0) | 116 (49.2) | 0.645 |
Non-ICU | 335 (73.6) | 120 (35.9) | 125 (53.0) | 120 (50.8) | ||
Invasive device, n (%) | ||||||
Central venous catheter | 249 (44.1) | 113 (45.) | 0.709 | 168 (71.2) | 101 (42.8) | < 0.001 |
Cardiac device | 46 (8.2) | 8 (3.2) | 0.009 | 13 (5.5) | 7 (3.0) | 0.170 |
Prosthetic device | 23 (4.1) | 8 (3.2) | 0.559 | 12 (5.1) | 8 (3.4) | 0.361 |
Site of BSI acquisition, n (%) | ||||||
Community-acquired | 234 (41.4) | 93 (37.5) | 0.286 | 63 (26.7) | 91 (38.6) | 0.006 |
Hospital-acquired | 330 (58.5) | 155 (62.5) | 173 (73.3) | 145 (61.4) | ||
Source of BSI, n (%) | ||||||
Primary BSI | 244 (43.2) | 104 (41.9) | 0.725 | 100 (42.4) | 100 (42.4) | 1.00 |
Secondary BSI | 320 (56.8) | 144 (58.1) | 136 (57.6) | 136 (57.6) | ||
Skin and soft tissue infection | 16 (2.8) | 6 (2.4) | 5 (2.1) | 6 (2.5) | ||
Gastrointestinal tract infection | 41(7.3) | 20 (8.1) | 9 (3.8) | 20 (8.5) | ||
Genitourinary tract infection | 87 (15.4) | 34 (13.7) | 16(6.8) | 33 (14.0) | ||
Respiratory tract infection | 37 (6.6) | 29 (11.7) | 17 (7.2) | 27 (11.4) | ||
Central venous catheter infection | 135 (23.9) | 55 (22.2) | 87 (36.9) | 50 (21.2) | ||
Other infection | 4 (0.7) | 0 (0) | 2 (0.8) | 0 (0) | ||
Microorganisms in BSI, n (%) | ||||||
Enterobacterales | 377 (66.8) | 155 (62.5) | 0.230 | 143 (60.6) | 150 (63.6) | 0.507 |
Escherichia coli | 173 (30.7) | 74 (29.8) | 59 (25.0) | 72 (30.6) | ||
Klebsiella spp. | 142 (25.1) | 55 (22.2) | 62 (26.3) | 53 (22.5) | ||
Enterobacter spp. | 35 (6.2) | 13 (5.2) | 13 (5.5) | 12 (5.1) | ||
Serratia spp. | 8 (1.4) | 4 (1.6) | 3 (1.3) | 4 (1.7) | ||
Proteus spp. | 7 (1.2) | 5 (2.09) | 2 (0.8) | 5 (2.1) | ||
Morganella spp. | 5 (0.9) | 2 (0.8) | 3 (1.3) | 2 (0.8) | ||
Salmonella spp. | 5 (0.9) | 1 (0.4) | 1 (0.4) | 1 (0.4) | ||
Citrobacter spp. | 2 (0.4 | 1 (0.4) | 0 (0.0) | 1 (0.4) | ||
P. aureginosa | 37 (6.6) | 24 (9.7) | 0.121 | 16 (6.8) | 24 (10.2) | 0.186 |
A.baumannii | 50 (8.9) | 32 ( 12.9) | 0.079 | 34 (14.4) | 28 (11.9) | 0.414 |
S. maltophlia | 44 (7.8) | 18 (7.3) | 0.788 | 20 (8.5) | 216 (6.8) | 0.488 |
Others* | 56 (9.9) | 19 (7.7) | 0.304 | 23 (9.7) | 18 (7.6) | 0.414 |
CR-GN | 130 (25.3) | 72 (31.4) | 0.082 | 74 (34.7) | 65 (29.7) | 0.260 |
MDR | 173 (30.7) | 83 (32.4) | 0.430 | 73 (47.4) | 81 (52.6) | 0.432 |
XDR | 76 (13.5) | 38 (15.3) | 0.485 | 42 (17.8) | 34 (14.4) | 0.316 |
PDR | 6 (1.1) | 7 (2.8) | 0.066 | 3 (1.3) | 6 (2.5) | 0.313 |
Follow-up duration (days), median (IQR) | 17 (11–27) | 12 (6–24) | < 0.001 | 17 (11–30) | 12 (7–24) | < 0.001 |
Follow-up duration days in patients without mortality, median (IQR) | 18 (13–30) | 15.5(9–30) | 0.003 | 21 (15–30) | 15 (9–30) | < 0.001 |