Table 2 Clinical characteristics and outcome

SOFA day0^{a, f}

5(3–7)

6(4–7)

5(3–8)

5(4–7)

0.8020

 <  = 5

248(52.4%)

26(49.1%)

94(54.3%)

128(51.8%)

0.7834

 5 ~ 7

111(23.5%)

14(26.4%)

35(20.2%)

62(25.1%)

 > 7

114(24.1%)

13(24.5%)

44(25.4%)

57(23.1%)

SOFA day5^{a, f}

4(3–8)

4(3–7)

4(2–7)

4(4–9)

 < .0001^***

 <  = 4

186(39.3%)

26(49.1%)

80(46.2%)

80(32.4%)

0.0201^*

 4 ~ 8

184(38.9%)

19(35.9%)

62(35.8%)

103(41.7%)

 > 8

103(21.8%)

8(15.1%)

31(17.9%)

64(25.9%)

Delta SOFA^{b, f}

 < .0001^***

 < 0

185(39.1%)

12(22.6%)

47(27.2%)

126(51.0%)

 >  = 0

288(60.9%)

41(77.4%)

126(72.8%)

121(49.0%)

Surgical status

88(18.6%)

9(17.0%)

26(15.0%)

53(21.5%)

0.2369

Pathogen detection^c

 < .0001^***

 Culture negative

148(31.3%)

28(52.8%)

58(33.5%)

62(25.1%)

 MDR^d

135(28.5%)

12(22.6%)

28(16.2%)

95(38.5%)

 Non-MDR^d

96(20.3%)

6(11.3%)

34(19.7%)

56(22.7%)

 Colonization or contamination

45(9.5%)

5(9.4%)

22(12.7%)

18(7.3%)

 No samples submitted or discharged

49(10.4%)

2(3.8%)

31(17.9%)

16(6.5%)

Mechanical ventilation

355(75.1%)

33(62.3%)

121(69.9%)

201(81.4%)

0.0021^**

Central venous catheterization

227(48.0%)

20(37.7%)

72(41.6%)

135(54.7%)

0.0089^**

Indwelling drainage tube

173(36.6%)

13(24.5%)

59(34.1%)

101(40.9%)

0.0563

Hemodialysis

118(24.9%)

7(13.2%)

46(26.6%)

65(26.3%)

0.1109

Empirical antimicrobial prescription

 < .0001^***

 Monotherapy

330(69.8%)

19(35.9%)

135(78.0%)

176(71.3%)

 2 agents

111(23.5%)

26(49.1%)

28(16.2%)

57(23.1%)

 > 2 agents

32(6.8%)

8(15.1%)

10(5.8%)

14(5.7%)

Relapse of infection^e

0(0%)

0(0%)

0(0%)

0(0%)

-

Duration of antimicrobial therapy (days)^f

8(5–15)

9(5–14)

8(4–13)

9(6–16)

0.0054^**

Length of ICU stay (days)^f

8 (5–15)

9(5–14)

8(4–14)

9(7–16.5)

0.0041^**

Cure rate

250(52.9%)

37(69.8%)

106(61.2%)

107(43.4%)

 < .0001^***

14-day mortality

79(16.7%)

5(9.4%)

20(11.6%)

54(21.9%)

0.0066^**