Fig. 4
From: Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection
MM expression level in CD4+ T cells of different differentiation status. (A) Flow cytometry showing naive (CD45RA+CCR7+), central memory (CD45RA–CCR7+) and effector memory (CD45RA–CCR7–) and terminally differentiated cells (CD45RA+CCR7–) subset gating strategies. The frequency of naive, central memory, and effector memory CD4+T subsets in peripheral blood CD4+T cells from HD, UNT and ART. (B) MMhigh percentage was measured in naive, central memory and effector memory CD4+T subsets in peripheral blood from HD, UNT and ART. Note: Only the p-values indicating statistical differences are marked. (C) The correlation between the MFI of MM in CD4+T cells and the percentage of effector memory (CD45RA–CCR7–) CD4+T subsets in the context of HIV infection (UNT and ART). The correlation between the frequency of effector memory (CD45RA–CCR7–) CD4+T subsets and the percentage of caspase-1(+) CD4+T from HIV-infected patients regardless of whether under ART (n = 60)