Fig. 3
From: Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection
HLA-DR expression, although a negative correlate of MM, does not explain the pyroptosis of CD4+ T cells. (A) Flow cytometry showing HLA-DR expression gating in CD4+T cells. The frequency of HLA-DR(+) CD4+T subsets in peripheral blood from HD, UNT and ART. (B) MMhigh percentages were measured in HLA-DR(+) and HLA-DR(–) CD4+T cells in peripheral blood from HD, UNT and ART. (C) The correlation between the MFI of MM in CD4+T cells and HLA-DR expression level in the context of HIV infection (UNT and ART) (r=–0.3317, p = 0.0005). The correlation between the frequency of HLADR expression level and the percentage of caspase-1(+) CD4+T from HIV-infected patients regardless of whether under ART (UNT and ART) (n = 60)