Fig. 2
From: Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection
MMhigh CD4+ T cells from HIV patients are predisposed to pyroptosis. (A) Percentages of caspase-1(+) in CD4+T cells from HD, UNT, ART. IL-18 and IL-1β in plasma from HD, UNT, and ART. (B) Pyroptosis was measured in MMhigh and MMlow CD4+T cells by caspase-1 staining. Pooled data showing the percentage (%) of caspase-1(+) T cells in MM high and MM low CD4+T cells and the MFI of MM in caspase-1(+) CD4+T cells and caspase-1(–) CD4+T cells. (C) The correlation between the frequency of MMhigh CD4+T cells and the percentage of caspase-1(+) CD4+T from HIV-infected patients regardless of whether under antiretroviral therapy (n = 60). The correlation between the MFI of MM in CD4+T cells and caspase-1 expression level in the context of HIV infection (UNT and ART). (D) The correlation between the the level of IL-18, IL-1β and percentages of caspase-1(+) in CD4+T cells with viral load and CD4+T cell counts in UNT.