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Table 2 Characteristics of the index encounter

From: Clinical burden of invasive Escherichia coli disease among older adult patients treated in hospitals in the United States

 

All patients

Type of IED at index date

Group 1

Group 2

P-value

Group 1 with sepsis

Group 2

P-value

N = 19,773

 N = 10,235

 N = 9,538

 N = 5,978

 N = 9,538

Onset of IED, n (%)

       

Hospital-onset

1,125 (5.7)

402 (3.9)

723 (7.6)

< 0.0001

208 (3.5)

723 (7.6)

< 0.0001

Community-onset

18,648 (94.3)

9,833 (96.1)

8,815 (92.4)

< 0.0001

5,770 (96.5)

8,815 (92.4)

< 0.0001

Healthcare-associated community-acquired

4,787 (25.7)

2,289 (23.3)

2,498 (28.3)

< 0.0001

1,416 (24.5)

2,498 (28.3)

< 0.0001

Non-healthcare-associated community-acquired

13,861 (74.3)

7,544 (76.7)

6,317 (71.7)

< 0.0001

4,354 (75.5)

6,317 (71.7)

< 0.0001

Infection type, n (%)

       

Urosepsis without bacteremia

9,538 (48.2)

0 (0.0)

9,538 (100.0)

-

0 (0.0)

9,538 (100.0)

-

Urosepsis with bacteremia

5,791 (29.3)

5,791 (56.6)

0 (0.0)

-

3,207 (53.6)

0 (0.0)

-

Cholangitis

299 (1.5)

297 (2.9)

2 (0.0)

< 0.0001

213 (3.6)

2 (0.0)

< 0.0001

Peritonitis

179 (0.9)

179 (1.7)

0 (0.0)

-

124 (2.1)

0 (0.0)

-

Other intra-abdominal infection

1 (0.0)

1 (0.0)

0 (0.0)

-

0 (0.0)

0 (0.0)

-

Neutropenic fever

166 (0.8)

127 (1.2)

39 (0.4)

< 0.0001

73 (1.2)

39 (0.4)

< 0.0001

Wound/surgical site infection

157 (0.8)

157 (1.5)

0 (0.0)

-

84 (1.4)

0 (0.0)

-

Osteomyelitis

39 (0.2)

39 (0.4)

0 (0.0)

-

27 (0.5)

0 (0.0)

-

Prostate biopsy-related infection

9 (0.0)

9 (0.1)

0 (0.0)

-

4 (0.1)

0 (0.0)

-

Meningitis

7 (0.0)

7 (0.1)

0 (0.0)

-

2 (0.0)

0 (0.0)

-

Complicated pneumonia

0 (0.0)

0 (0.0)

0 (0.0)

-

0 (0.0)

0 (0.0)

-

Other blood stream infections

3,774 (19.1)

3,774 (36.9)

0 (0.0)

-

2,334 (39.0)

0 (0.0)

-

Other

37 (0.2)

37 (0.4)

0 (0.0)

-

25 (0.4)

0 (0.0)

-

Type of encounter, n (%)

       

Inpatient stay

19,084 (96.5)

9,546 (93.3)

9,538 (100.0)

< 0.0001

5,978 (100.0)

9,538 (100.0)

-

Duration of inpatient stay (days), mean ± SD [median]

6.9 ± 5.7 [5.0]

6.4 ± 5.6 [5.0]

7.4 ± 5.8 [6.0]

< 0.0001

7.2 ± 5.9 [6.0]

7.4 ± 5.8 [6.0]

0.3166

Duration of inpatient stay after the first positive E. coli culture, mean ± SD [median]

6.5 ± 5.1 [5.0]

6.1 ± 4.9 [5.0]

6.9 ± 5.2 [6.0]

< 0.0001

6.9 ± 5.3 [6.0]

6.9 ± 5.2 [6.0]

0.0587

Emergency room visit

554 (2.8)

554 (5.4)

0 (0.0)

-

0 (0.0)

0 (0.0)

-

Outpatient hospital visit

135 (0.7)

135 (1.3)

0 (0.0)

-

0 (0.0)

0 (0.0)

-

ICU admission, n (%)

6,405 (32.4)

3,029 (29.6)

3,376 (35.4)

< 0.0001

2,584 (43.2)

3,376 (35.4)

< 0.0001

Duration of ICU stay (days), mean ± SD [median]

3.7 ± 4.1 [2.0]

3.5 ± 4.1 [2.0]

3.9 ± 4.0 [3.0]

< 0.0001

3.6 ± 4.1 [2.0]

3.9 ± 4.0 [3.0]

< 0.0001

Time between admission and ICU transfer, mean ± SD [median]

0.8 ± 2.4 [0.0]

0.7 ± 2.7 [0.0]

0.8 ± 2.1 [0.0]

< 0.0001

0.6 ± 2.3 [0.0]

0.8 ± 2.1 [0.0]

< 0.0001

ICU transfer on the same day as admission, n (%)

4,774 (74.5)

2,322 (76.7)

2,452 (72.6)

0.0002

1,990 (77.0)

2,452 (72.6)

0.0001

Mechanical ventilation, n (%)

1,710 (8.6)

707 (6.9)

1,003 (10.5)

< 0.0001

667 (11.2)

1,003 (10.5)

0.2094

  1. Abbreviations: ICU: intensive care unit; IED: invasive Escherichia coli disease; SD: standard deviation
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BMC Infectious Diseases

ISSN: 1471-2334

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