Fig. 1

IED type

Abbreviations: CDC: Centers for Disease Control; IED: invasive Escherichia coli disease

Notes:Notes: ^a Normally sterile body sites include cerebrospinal fluid, pleural fluid (chest fluid, thoracentesis fluid), peritoneal fluid (abdominal fluid, ascites), pericardial fluid, bone (including bone marrow), joint fluid (synovial fluid, fluid, needle aspirate, or culture of any specific joint such as knee, ankle, elbow, hip, wrist), and internal body sites (lymph node, brain, heart, liver, spleen, vitreous fluid, kidney, pancreas, ovary, vascular tissue, deep wound)

^b The sepsis clinical surveillance definition utilizes an algorithm defined by Rhee et al. (2017) and details and diagnosis codes were updated using the CDC’s Hospital Toolkit for Adult Sepsis Surveillance (March 2018). The algorithm was validated using medical records from 510 randomly selected hospitalizations, stratified into those that did and did not meet sepsis surveillance criteria