Table 1 Inclusion and exclusion criteria for Umoya and Teen TB studies
From: SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study
Inclusion | Exclusion | ||
|---|---|---|---|
Umoya | Cases | Any child aged < 13 years identified in hospital (inpatient or outpatient) with suspected pulmonary TB who: • Meets the criteria for confirmed TB or unconfirmed TB based on recent consensus agreement [18] | • Receipt of TB treatment for more than two days in the previous 14 days • Severe illness resulting in unstable condition • Any condition which would constitute an absolute contra-indication to any of the sampling procedures required by the study • Residence in remote areas with no ready access to transport for follow-up visits • Presence of only extra-thoracic TB without evidence of pulmonary TB |
Controls (asymptomatic) | • Asymptomatic siblings of children enrolled with suspected pulmonary TB | • Severe illness resulting in unstable condition • Any condition which would constitute an absolute contra-indication to any of the sampling procedures required by the study | |
Controls (symptomatic) | • Symptomatic children who were evaluated in hospital and met the criteria for unlikely TB | ||
Teen TB | Cases | Any adolescent (10 to < 20 years) who has: • A primary diagnosis of newly diagnosed pulmonary TB bacteriologically confirmed on sputum (Xpert- or culture-positive), with or without HIV coinfection • And are within the first 14 days since diagnosis and thus 14 days of TB treatment | • Extrapulmonary TB without evidence of pulmonary TB • Severe illness or any condition causing the participant to be clinically unstable or require intensive care treatment • Pregnancy or breastfeeding • Diabetes Mellitus • Participants declining HIV testing for whom a recent (< 12 month) HIV test result is not available |
Controls | Any adolescent (10 to < 20 years): • Exposed in their household in the last 6 months to a case of infectious pulmonary TB • Has no symptoms of TB | • Previous TB disease • Severe illness or any condition causing the participant to be clinically unstable or require intensive care treatment • Pregnancy or breastfeeding • Diabetes Mellitus • Participants declining HIV testing for whom a recent (< 12 month) HIV test result is not available |