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Table 1 Demographic and clinical characteristics of the patients in the ETA group and BALF group

From: Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case–control study

 

ETA Group

(n = 53)

BALF Group

(n = 106)

P value

Age (years), mean ± sd

66.12 ± 15.98

65.42 ± 16.49

0.150

Gender (female), n (%)

14 (26)

28 (26)

1

Type of pneumonia (HAP), n (%)

41 (87.4)

82 (87.4)

1

APACHE II score, mean ± sd

16.30 ± 3.36

16.90 + 2.98

0.372

PSI, n (%)

 Grade III

13 (24.5)

26 (24.5)

1

 Grade IV

39 (73.6)

78 (73.6)

1

 Grade V

1 (1.9)

2 (1.9)

1

Primary disease, n (%)

 Disease of cardiovascular system

25 (47.2)

50 (47.2)

1

 Autoimmune diseases

12 (22.6)

24 (22.6)

1

 Diabetes

12 (22.6)

24 (22.6)

1

 Diseases of urinary system

11 (20.8)

22 (20.8)

1

 Nervous system diseases

8 (15.1)

16 (15.1)

1

 Disease of respiratory system

3 (5.7)

6 (5.7)

1

 Tumor

5 (9.4)

10 (9.4)

1

 Others

3 (5.7)

6 (5.7)

1

 None

3 (5.7)

6 (5.7)

1

 Time from diagnosis of severe pneumonia to ICU admission (h), median (IQR)

20 (10.25, 35)

22.5 (13.25, 35.75)

0.499

 Time from ICU admission to specimen submission (h), median (IQR)

9.5 (4, 13)

14 (5, 19)

0.400

 Time from specimen submission to the intervention (h)

22.5 (19.5, 26)

23 (19, 26.5)

0.379

Laboratory examinationa

 White blood cell count (× 109/L), mean ± sd

12.47 ± 6.31

11.94 ± 6.71

0.709

 Neutrophils (%), mean ± sd

86.38 ± 7.27

87.80 ± 7.87

0.420

 CRP (mg/L), median (IQR)

87.83 (49.83, 180.86)

85.64 (60.12, 117.37)

0.899

 PCT (ng/mL), median (IQR)

1.31 (0.208, 7.62)

1.223 (0.314, 6.2)

0.785

  1. Abbreviation: ETA Endotracheal aspirates, BALF Bronchoalveolar lavage fluid, sd standard deviation, HAP Hospital acquired pneumonia, APACHE II Acute physiology and chronic health evaluation II, PSI Pneumonia severity index, CRP C-reactive protein, IQR Interquartile range, PCT Procalcitonin, ICU Intensive care unit
  2. aLaboratory test results of the day of mNGS specimen collection