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Table 3 Comparison of clinical features among patients with mild and moderate/severe disease

From: Risk factors for disease severity among children with Covid-19: a clinical prediction model

 

Mild Disease

(n = 1,023)

Moderate/severe Disease

(n = 211)

p-value

Demography

 Age in years, median (IQR)

3·1 (1·0 – 7·6)

1·9 (0·7 – 6·2)

< 0·001c

 Male sex

511 (49·9%)

121 (57·3%)

0·05d

 Malay ethnicity

844 (82·5%)

183 (86·7%)

0·09d

Previous COVID-19 infectiona

6 (0·6%)

0 (0%)

0·60d

Obesity

35 (3·4%)

13 (6·2%)

0·06d

Any comorbidities

77 (7·5%)

39 (18·5%)

< 0·001d

Type of Comorbidities

 Respiratory

34 (3·3%)

11 (5·2%)

0·18d

 Prematurity (if age < 2 years)b

21 (2·1%)

7 (3·3%)

0·26d

 Cardiovascular

15 (1·5%)

9 (4·3%)

0·01d

 Genetic

10 (1·0%)

6 (2·8%)

0·03d

 Neuromuscular

7 (0·7%)

8 (3·8%)

< 0·001d

 Gastrointestinal

2 (0·2%)

4 (1·9%)

0·001e

 Others

10 (1·0%)

4 (1·9%)

0·25d

Symptoms

 Fever

793 (77·5%)

178 (84·4%)

0·03d

 Cough

419 (41·0%)

88 (41·7%)

0·84d

 Rhinorrhea

377 (36·9%)

65 (30·8%)

0·10d

 Sore throat

36 (3·5%)

5 (2·4%)

0·40d

 Shortness of breath

10 (1·0%)

43 (20·4%)

< 0·001d

 Vomiting

65 (6·4%)

52 (24·6%)

< 0·001d

 Diarrhea

63 (6·2%)

35 (16·6%)

< 0·001d

 Seizures

11 (1·1%)

22 (10·4%)

< 0·001d

 Rash

22 (2·2%)

11 (5·2%)

0·01d

 Anosmia/ageusia

44 (4·3%)

3 (1·4%)

0·05d

Physical Findings

 Temperature on arrival in ºC, median (IQR)

36·6 (36·4 – 36·8)

37·0 (36·8 – 38·0)

< 0·001c

 Chest recessions

2 (0·2%)

42 (19·9%)

< 0·001d

 Abnormal breath sounds

3 (0·3%)

21 (10·0%)

< 0·001d

  1. IQR Interquartile range
  2. aA documented history of COVID-19 more than 3 months prior to the current hospitalization
  3. bGestational age < 37 weeks at birth among children aged < 2 years
  4. cMann-Whitney U Test,
  5. dChi-squared test
  6. eFisher's exact test