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Table 2 Incidences of plasma CMV viral load testing performed in intervals of less than five days, CMV DNAemia, and CMV diseases

From: Diagnostic stewardship to limit repeat plasma cytomegalovirus viral load testing

 

Pre-intervention (N = 1,764)

Post-intervention (N = 1,674)

Incidence rate ratio (95% CI)

p-value

Plasma CMV VL testing ordered in intervals < 5 days before the feedback [n (%)]

308 (17.5)

173 (10.3)

0.51 (0.43–0.62)

< 0.001

Plasma CMV VL testing ordered in intervals < 5 days after the feedback [n (%)]

N/A

134 (8.0)

0.40 (0.33–0.43)

< 0.001

 

Pre-intervention (N = 291)

Post-intervention (N = 318)

Risk ratio (95% CI)

p-value

CMV DNAemia

124 (42.6)

125 (39.3)

0.92 (0.76–1.11)

0.407

Plasma CMV VL > 1,000 IU/mL

86 (29.6)

101 (31.8)

1.07 (0.85–1.37)

0.556

CMV disease

30 (10.3)

37 (11.6)

1.13 (0.72–1.78)

0.602

    CMV pneumonitis

13 (4.5)

20 (6.3)

  

    CMV retinitis

7 (2.4)

3 (0.9)

  

    CMV gastrointestinal disease

10 (3.4)

11 (3.5)

  
  1. Abbreviations: CI Confidence interval, CMV Cytomegalovirus, IU International unit, mL Milliliter, N/A Not applicable, VL Viral load