From: Diagnostic stewardship to limit repeat plasma cytomegalovirus viral load testing
 | Pre-intervention (N = 291) | Post-intervention (N = 318) | p-value |
---|---|---|---|
Age (years) [median (IQR)] | 55 (38–68) | 60 (47–71) | 0.001 |
Male gender [n (%)] | 154 (52.9) | 144 (45.3) | 0.060 |
Ward | Â | Â | 0.032 |
 General ward [n (%)] | 206 (70.8) | 199 (62.6) |  |
 Intensive care unit [n (%)] | 85 (29.2) | 119 (37.4) |  |
Comorbidities [n (%)] | 271 (93.1) | 298 (93.7) | 0.772 |
Solid organ transplantation [n (%)] | 74 (25.4) | 39 (12.3) | < 0.001 |
 Kidney | 67 (90.5) | 36 (92.3) |  |
 Liver | 4 (5.4) | 0 (0.0) |  |
 Heart | 3 (4.0) | 3 (7.7) |  |
HSCT [n (%)] | 21 (7.2) | 25 (7.9) | 0.763 |
 ASCT | 7 (33.3) | 3 (12.0) |  |
 MSD | 6 (28.6) | 11 (44.0) |  |
 MUD | 8 (38.1) | 9 (36.0) |  |
 MMD | 0 (0.0) | 2 (8.0) |  |
 Patients with GVHD | 4 (19.1) | 11 (44.0) |  |
Autoimmune diseases [n (%)] | 62 (21.3) | 66 (20.8) | 0.868 |
 SLE | 29 (46.8) | 24 (36.4) |  |
 Systemic vasculitides | 6 (9.7) | 7 (10.6) |  |
 Rheumatoid arthritis | 5 (8.1) | 3 (4.5) |  |
 Inflammatory myositis | 1 (1.6) | 6 (9.1) |  |
 Systemic sclerosis | 4 (6.5) | 4 (6.1) |  |
Leukemia [n (%)] | 39 (13.4) | 32 (10.1) | 0.200 |
Lymphoma [n (%)] | 24 (8.3) | 28 (8.8) | 0.806 |
Solid malignancy [n (%)] | 14 (4.8) | 7 (2.2) | 0.078 |
HIV [n (%)] | 13 (4.5) | 8 (2.5) | 0.187 |
COVID-19 [n (%)] | 0 (0.0) | 69 (21.7) |  < 0.001 |
Pretransplant CMV IgG in HSCT patients [n (%)] | Â | Â | 0.261 |
 Unavailable | 16 (76.2) | 16 (64.0) |  |
 D + /R +  | 4 (19.1) | 9 (36.0) |  |
 D + /R- | 1 (4.8) | 0 (0.0) |  |
Pretransplant CMV IgG status in solid organ transplant patients [n (%)] | Â | Â | 0.717 |
 Unavailable | 14 (18.9) | 4 (10.3) |  |
 D + /R +  | 55 (74.3) | 33 (84.6) |  |
 D + /R- | 3 (4.1) | 2 (5.1) |  |
 D-/R +  | 1 (1.4) | 0 (0.0) |  |
 D-/R- | 1 (1.4) | 0 (0.0) |  |
Immunosuppressive used [n (%)] | Â | Â | Â |
 Corticosteroid | 160 (55.0) | 181 (56.9) | 0.631 |
 Prednisolone > 20 mg/day | 79 (27.2) | 124 (39.0) | 0.002 |
 Tacrolimus | 54 (18.6) | 34 (10.7) | 0.006 |
 Cyclosporin | 33 (11.3) | 27 (8.5) | 0.239 |
 Cyclophosphamide | 28 (9.6) | 21 (6.6) | 0.171 |
 Mycophenolic acid | 65 (22.3) | 50 (15.7) | 0.037 |
 mTOR inhibitor | 8 (2.8) | 2 (5.2) | 0.054 |
 Antithymocyte globulin | 17 (5.8) | 14 (4.4) | 0.420 |