Skip to main content

Table 1 Basic information of the included studies

From: Declining incidence rate of tuberculosis among close contacts in five years post-exposure: a systematic review and meta-analysis

First author, publish year

Study design

Study site

Index cases

Close contacts

No

Age (years) range/mean ± SD/ median(IQR), gender (%)

Diagnosis

No

Age (years) range/mean ± SD/ median(IQR), gender(%)

Exposure classificationa

Yassin MA, 2020 [4]

Prospective

Ethiopia

344

35 (26–45), male (57)

Smear + 

1,517

18 (12–30), male (57)

HHC

Araujo NCN, 2020 [13]

Retrospective

Brazil

1,672

NA

Microbiologically confirmed

1,264

9 (4–12), male (54)

HHC and non-HHC

Saunders MJ, 2019 [5]

Retrospective

Callao, Peru

715

27 (20–36), male (59)

Microbiologically confirmed

2,666

29 (21–42), male (46)

HHC

Huerga H, 2019 [14]

Prospective

Yerevan, Armenia

79

 > 15, NA

Microbiologically confirmed

150

 < 15, male (47)

HHC and non-HHC

Benjumea-Bedoya D, 2019 [15]

Prospective

Colombia

380

NA

Smear + 

1,040

 < 15, male (51)

HHC

Becerra MC, 2019 [16]

Prospective

Lima, Peru

2,516

 > 16, NA

Microbiologically confirmed

10,160

All ages, male (45)

HHC

Reichler MR, 2018 [17]

Prospective

USA & Canada

718

 > 15, NA

Microbiologically confirmed

4,490

NA

HHC and non-HHC

Martinez L, 2018 [18]

Prospective

Kampala, Uganda

857

 > 18, NA

Microbiologically confirmed

1,718

 < 16, male (33)

HHC and non-HHC

Baliashvili D, 2018 [19]

Retrospective

Gerogia, USA

896

41 ± 17, male (75)

Smear + 

3,313

32 ± 21 male (43)

HHC and non-HHC

Sharma SK, 2017 [20]

Prospective

New Delhi, India

342

18–65, NA

Smear + 

1,511

24 ± 15, male (52)

HHC

Puma DV, 2017 [21]

Retrospective

Catalonia, Spain

26

35 ± 17, male (66)

NA

103

29 ± 18, male (60)

HHC

Munoz L, 2017 [22]

Retrospective

Barcelona, Spain

360

NA

Microbiologically confirmed

661

37 (26–49), male (47)

HHC and non-HHC

Triasih R, 2015 [23]

Prospective

Indonesia

141

NA

Microbiologically confirmed

269

 < 15, NA

HHC and non-HHC

Chakhaia T, 2014 [24]

Retrospective

Tbilisi, Georgia

396

 ≥ 5, male (63)

Microbiologically confirmed

869

All ages, male (43)

HHC and non-HHC

Singh J, 2013 [25]

Prospective

India

432

34 ± 14, male (58)

Microbiologically confirmed

1,608

27 ± 16, male (54)

HHC and non-HHC

Haldar P, 2013 [26]

Prospective

UK

505

NA

Microbiologically confirmed

1,671

 ≥ 16, male (50)

HHC and non-HHC

Wang JY, 2012 [27]

Prospective

China

NA

NA

NA

600

NA

HHC

Song S, 2012 [28]

Retrospective

South Korea

44

NA

Clinical confirmed / Microbiologically confirmed

1,826

18, male (51)

Non-HHC

Denholm JT, 2012 [29]

Retrospective

Victoria, Australia

47

NA

NA

570

28 (18–37), male (44)

Non-HHC

Becerra MC, 2011 [30]

Retrospective

Peru

693

NA

Microbiologically confirmed

4,503

25 ± 19, male (49)

HHC

Lienhardt C, 2010 [31]

Prospective

Dakar, Senegal

206

28 (18–71), male (68)

Smear + 

2,762

20 (10–31), male (54)

HHC

del Corral H, 2009 [32]

Prospective

Colombia

366

36 (24–50), male (57)

Smear + 

2,060

22 (10–42), male (43)

HHC

Cailleaus M, 2009 [33]

Retrospective

Brazil

276

NA

Microbiologically confirmed

1,178

 ≥ 12, male (38)

HHC and non-HHC

Hill PC, 2008 [34]

Prospective

Gambia

317

NA

Smear + 

2,381

NA

HHC

Diel R, 2008 [35]

Prospective

Germany

107

28 ± 12, male (49)

Smear + 

629

26 ± 14, NA

Non-HHC

Lemos AC, 2004 [36]

Prospective

Bahia, Brazil

69

29 ± 12, male (70)

Smear + 

269

26 ± 17, male (50)

HHC

Bayona J, 2003 [37]

Prospective

Lima, Peru

192

NA, male (55)

Microbiologically confirmed

945

All ages, male (45)

HHC

Devadatta S, 1970 [38]

Prospective

Madras, India

NA

NA

NA

875

All ages, NA

HHC and non-HHC

Kamat SR, 1966 [39]

Prospective

Madras, India

NA

NA

NA

435

All ages, male (50)

HHC and non-HHC

Ramakrishnan CV, 1961 [40]

Prospective

Madras, India

NA

NA

NA

612

All ages, male (50)

HHC and non-HHC

Andrews RH, 1960 [41]

Prospective

Madras, India

193

NA

NA

672

All ages, male (50)

HHC and non-HHC

  1. Abbreviation: HHC Household contact, IQR Inter quartile range, NA Not available, SD Standard deviation, smear + smear positive
  2. aClose contact was defined as either household contacts or non-household contacts: most articles defined household contact as a person who had shared the same enclosed living space with the index case for more than one or more nights or for frequent or extended daytime periods during the 3 months before the start of current treatment; most studies defined non-household contact as a person who was not in the household but shared an enclosed space (such as a social gathering, workplace or facility) for extended periods during the day with index case during the 3 months before commencement of the current TB treatment episode