Table 3 Most relevant clinical features by clinical diagnosis and RT-qPCR confirmation, for differentiating arboviral infections from other febrile infections

A. Clinical Diagnosis

Binary^a

Multinomial

Arbovirus

Dengue

Chikungunya

Zika

Variables

OR

CI 95%

Variables

OR

CI 95%

Variables

OR

CI 95%

Variables

OR

CI 95%

Arthritis

7.49

0.59–95.97

Conjunctivitis^d

3.19^*

1.31–7.81

Arthralgia^b,c,d

27.44^*

5.58–134.89

Rash^d

25.43^*

6.18–104.55

Conjunctivitis^d

4.09^*

1.76–9.52

Retro orbital pain^b

3.04^*

1.62–5.73

Photophobia

5.73^*

1.65–19.93

Conjunctivitis^d

12.78^*

3.24–50.35

Retro orbital pain^b

3.34^*

1.76–6.31

Arthralgia^b,c,d

2.84^*

1.46–5.52

Dizziness

3.94^*

1.38–11.28

Arthralgia^b,c,d

2.97

0.89–9.88

Arthralgia^b,c,d

3.25^*

1.64–6.46

Rash^d

2.48

0.80–7.65

Rash^d

3.31

0.86–12.77

Photophobia

2.83

0.67–11.88

Rash^d

2.62

0.89–7.71

Photophobia

2.07

0.69–6.19

Conjunctivitis

2.73

0.90–8.27

Retro orbital pain^b

1.25

0.41–3.87

Myalgia

2.03^*

1.02–4.07

Dizziness

1.01

0.51–2.02

Retro orbital pain^b

2.42

0.96–6.13

Hematocrit

1.24^*

1.09–1.43

Platelets

0.99^*

0.98–0.99

Age

1.01

0.99–1.02

Age

1.03^*

1.00–1.06

Dizziness

1.19

0.37–3.85

White Blood Cells

0.77^*

0.69–0.86

Hematocrit

1.01

0.94–1.08

Neutrophils

1.02^*

1.00–1.04

Neutrophils

1.05^*

1.02–1.08

Anorexia

0.55

0.25–1.21

Neutrophils

1.01

0.99–1.02

Hematocrit

0.99

0.89–1.10

Age

1.03^*

1.00–1.06

Abdominal pain

0.40^*

0.21–0.76

Platelets

0.98^*

0.97–0.99

Platelets

0.99

0.99–1.00

Platelets

0.99

0.98–1.00

Cough

0.26^*

0.07–0.96

White Blood Cells

0.78^*

0.71–0.86

White Blood Cells

0.79^*

0.69–0.91

White Blood Cells

0.75^*

0.62–0.91

Pharyngeal Hyperemia

0.02^*

0.01–0.21

Abdominal pain

0.47^*

0.25–0.89

Abdominal pain

0.29^*

0.11–0.72

Abdominal pain

0.44

0.14–1.35

Pharyngeal Hyperemia

0.03^*

0.01–0.28

Pharyngeal Hyperemia

NA

Pharyngeal Hyperemia

NA

B. RT-qPCR confirmation

Arbovirus

Dengue

Chikungunya

Zika

Variables

OR

CI 95%

Variables

OR

CI 95%

Variables

OR

CI 95%

Variables

OR

CI 95%

Pharyngeal Hyperemia

4.76^*

1.49–15.25

Hematocrit

1.16

0.98–1.37

Photophobia

2.33

0.50–10.89

Photophobia

2.26^*

1.29–3.97

Cough

3.70^*

1.07–12.84

White Blood Cells

1.08

0.98–1.37

Hematocrit

1.40

0.85–2.30

Hematocrit

1.40^*

1.18–1.66

Photophobia

1.72^*

1.06–2.79

Platelets

0.99^*

0.99–0.99

Platelets

1.00

0.99–1.01

White Blood Cells

0.99

0.91–1.09

Hematocrit

1.28^*

1.12–1.45

Lymphocytes

0.99

0.99–1.00

Lymphocytes

0.96

0.92–1.01

Platelets

0.99^*

0.99–0.99

Platelets

0.99^*

0.99–0.99

Photophobia

0.78

0.36–1.67

White Blood Cells

0.61

0.37–1.02

Lymphocytes

0.98^*

0.96–0.99

Lymph nodes

0.55

0.29–1.04

Hemoglobin

0.68

0.42–1.11

Hemoglobin

0.45

0.11–1.87

Vomit

0.54^*

0.31–0.97

Bloating

0.52

0.26–1.07

Vomit

0.50

0.25–1.01

Vomit

0.38

0.07–2.16

Hemoglobin

0.39^*

0.24–0.63

Hemoglobin

0.51^*

0.35–0.74

Vomit

0.48^*

0.30–0.78