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Table 2 Frequency and percentage of HPV detection in 67 women with and without plasma AFB1-lys detection, and mean (standard deviation, or STD) and median (interquartile range, or IQR) of plasma AFB1-lys concentration (pg/uL)

From: Association of plasma aflatoxin with persistent detection of oncogenic human papillomaviruses in cervical samples from Kenyan women enrolled in a longitudinal study

HPV

HPV detection category

Plasma AFB1-lys concentration (pg/uL)

Plasma AFB1-lys detection

N, Mean (STD)

Median (IQR)

P- Value13

No (N = 27)

n (%)

Yes (N = 40)

n (%)

P-Value

Any HPVa

No Detection

23, 0.030 (0.042)

0.000 (0.000-0.066)

0.036

14 (51.9)

9 (22.5)

0.04311

 

Incident Detection

32, 0.050 (0.043)

0.052 (0.000-0.088)

 

10 (37.0)

22 (55.0)

 
 

Persistent Detection

12, 0.078 (0.068)

0.081 (0.014–0.098)

 

3 (11.1)

9 (22.5)

 

HR-HPVb

No Detection

30, 0.034 (0.044)

0.000 (0.000-0.065)

0.020

17 (63.0)

13 (32.5)

0.03811

 

Incident Detection

26, 0.049 (0.041)

0.050 (0.000-0.091)

 

8 (29.6)

18 (45.0)

 
 

Persistent Detection

11, 0.086 (0.066)

0.082 (0.027–0.098)

 

2 (7.4)

9 (22.5)

 

IARC HR-HPVc

No Detection

35, 0.046 (0.057)

0.035 (0.000-0.073)

0.410

17 (63.0)

18 (45.0)

0.36112

 

Incident Detection

24, 0.048 (0.042)

0.046 (0.000-0.093)

 

8 (29.6)

16 (40.0)

 
 

Persistent Detection

8, 0.058 (0.042)

0.078 (0.014–0.093)

 

2 (7.4)

6 (15.0)

 

A9 HPVd

No Detection

45, 0.045 (0.053)

0.035 (0.000-0.073)

0.395

20 (74.1)

25 (62.5)

0.56712

 

Incident Detection

17, 0.055 (0.043)

0.067 (0.000-0.094)

 

5 (18.5)

12 (30.0)

 
 

Persistent Detection

5, 0.054 (0.049)

0.082 (0.000-0.089)

 

2 (7.4)

3 (7.5)

 

Non-HPV 16 A9e

No Detection

48, 0.044 (0.052)

0.031 (0.000-0.073)

0.171

22 (81.5)

26 (65.0)

0.17512

 

Incident Detection

15, 0.062 (0.041)

0.079 (0.023–0.095)

 

3 (11.1)

12 (30.0)

 
 

Persistent Detection

9, 0.047 (0.054)

0.045 (0.000-0.093)

 

2 (7.4)

2 (5.0)

 

A7 HPVf

No Detection

55, 0.048 (0.050)

0.047 (0.000-0.085)

0.097

23 (85.2)

32 (80.0)

0.23612

 

Incident Detection

8, 0.025 (0.029)

0.016 (0.000-0.050)

 

4 (14.8)

4 (10.0)

 
 

Persistent Detection

4, 0.096 (0.067)

0.086 (0.050–0.142)

 

0 (0.0)

4 (10.0)

 

Non-HPV 18 A7g

No Detection

59, 0.049 (0.048)

0.047 (0.000-0.085)

0.090

23 (85.2)

36 (90.0)

0.66112

 

Incident Detection

7, 0.024 (0.031)

0.000 (0.000-0.059)

 

4 (14.8)

3 (7.5)

 
 

Persistent Detection

1, 0.186 (-)

0.186 (0.186–0.186)

 

0 (0.0)

1 (2.5)

 

HR-HPV types not included in 9v HPV vaccineh

No Detection

41, 0.046 (0.054)

0.040 (0.000-0.073)

0.505

18 (66.7)

23 (57.5)

0.62512

 

Incident Detection

18, 0.047 (0.045)

0.042 (0.000-0.094)

 

7 (25.9)

11 (27.5)

 
 

Persistent Detection

8, 0.058 (0.042)

0.078 (0.014–0.093)

 

2 (7.4)

6 (15.0)

 

HR-HPV types included in the 9v HPV vaccinei

No Detection

47, 0.038 (0.044)

0.023 (0.000-0.079)

0.017

23 (85.2)

24 (60.0)

0.06412

 

Incident Detection

16, 0.054 (0.040)

0.063 (0.008–0.090)

 

4 (14.8)

12 (30.0)

 
 

Persistent Detection

4, 0.137 (0.071)

0.133 (0.077–0.198)

 

0 (0.0)

4 (10.0)

 

LR-HPVj

No Detection

44, 0.045 (0.047)

0.038 (0.000-0.081)

0.414

19 (70.4)

25 (62.5)

0.28412

 

Incident Detection

22, 0.057 (0.055)

0.058 (0.000-0.091)

 

7 (25.9)

15 (37.5)

 
 

Persistent Detection

1, 0.000 (-)

0.000 (0.000–0.000)

 

1 (3.7)

0 (0.0)

 
  1. aAny HPV: HPV 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 70, 71, 72, 73, 81, 82, 83, 84, CP6108, IS39
  2. b h-HPV (High-Risk HPV): HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 69, 70, 73, 82, IS39
  3. cIARC HR-HPV: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66
  4. dA9 HPV: HPV 16, 31, 33, 35, 52, 58
  5. eNon-HPV 16 A9: HPV 31, 33, 35, 52, 58
  6. fA7 HPV: HPV 18, 39, 45, 59, 68
  7. gNon-HPV 18 A7: HPV 39, 45, 59, 68
  8. h h-HPV types not included in the 9v HPV vaccine: HPV 26, 35, 39, 51, 53, 56, 59, 66, 67, 68, 69, 70, 73, 82, IS39
  9. i h-HPV types included in the 9v HPV vaccine: HPV 16, 18, 31, 33, 45, 52, 58
  10. jLR-HPV (Low-Risk HPV): HPV 6, 11, 40, 42, 54, 55, 61, 62, 64, 71, 72, 81, 83, 84, CP6108
  11. 11P-value from Chi-square test
  12. 12P-value from Fisher’s exact test
  13. 13P-value from Wilcoxon rank sum test
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BMC Infectious Diseases

ISSN: 1471-2334

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