Table 3 Differences between yeast and mold infections
Yeast infections (n=5) | Mold infections (n=23) | p | |
|---|---|---|---|
Site of disease | |||
Bloodstream disease | 5 (100%) | 0 (0%) | <0.001 |
Bronchopulmonary disease | 0 (0%) | 23 (100%) | <0.001 |
Sinonasal disease | 0 (0%) | 2 (8.7%) | 1.000 |
Age (years) | 1.8 (0.8-10.9) | 10.5 (6.6-15.2) | 0.053 |
Number of host factors | 1 (0-1) | 3 (2-4) | 0.001 |
Host factors | |||
Prolonged neutropenia | 0 (0%) | 9 (42.9%) | 0.502 |
Hematologic malignancy | 1 (20%) | 13 (56.5%) | 0.326 |
Allogeneic HSCT | 0 (0%) | 11 (47.8%) | 0.125 |
Prolonged use of corticosteroids | No data | 11 (50%) | - |
Acute GVHD | 0 (0%) | 5 (21.7%) | 0.550 |
Chronic GVHD | 0 (0%) | 4 (17.4%) | 1.000 |
Risk stratification | |||
High-risk | 0 (0%) | 20 (87%) | 0.001 |
Low-risk | 1 (20%) | 2 (8.7%) | 0.459 |
Sporadic | 4 (80%) | 1 (4.3%) | 0.001 |
Breakthrough IFD | 0 (0%) | 20 (87%) | 0.001 |
Laboratory parameters | |||
Hemoglobin (g/dl) | 9.5 (8.1-11) | 8.9 (7.9-10.7) | 0.880 |
Platelets x103/µL | 94 (71.5-163.5) | 39.5 (19.8-66.5) | 0.016 |
Leukocytes/µL | 1375 (1050-5350) | 1200 (200-5950) | 0.650 |
Neutrophils/µL | 440 (40-3250) | 100 (0-4250) | 0.705 |
Lymphocytes/µL | 860 (223-1530) | 500 (100-1050) | 0.496 |
CRP (mg/dl) at diagnosis | 1.1 (0.2-6.3) | 6.7 (2.6-12.7) | 0.113 |
Maximum CRP (mg/dl) | 13.9 (4-13.9) | 12 (3.3-20.7) | 0.787 |
Procalcitonin (ng/ml) at diagnosis | 2.2 (2.2-2.2) | 0.12 (0.1-0.2) | 0.333 |
Maximum procalcitonin (ng/ml) | 2.2 (2.2-2.2) | 0.6 (0.3-1.1) | 0.400 |
IFD diagnosis | |||
Proven IFD | 5 (100%) | 1 (4.3%) | 0.001 |
Probable IFD | 0 (0%) | 8 (34.8%) | 0.281 |
Possible IFD | 0 (0%) | 14 (60.9%) | 0.041 |
Treatment duration | 32 (15.5-60.5) | 43.5 (25-71) | 0.488 |
Outcome | |||
PICU admission | 1(20%) | 7 (30.4%) | 1.00 |
Mechanical ventilation | 0 (0%) | 4 (17.4%) | 1.00 |
Inotropic support | 0 (0%) | 3 (13%) | 1.00 |
Exitus | 0 (0%) | 6 (26.1%) | 0.553 |