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Table 2 Associations between HCW occupational factors and SARS-CoV-2 seropositivity of HCW study population and subgroups segregated by prior rt-PCR testing

From: Risk factors for SARS-CoV-2 seropositivity in a health care worker population during the early pandemic

 

All HCWs (n = 1,557)

Not tested by rt-PCR (n = 1,138)

Tested by rt-PCR (n = 419)

 

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

Adjusted OR

(95% CI)1

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

Adjusted OR

(95% CI)1

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

Adjusted OR

(95% CI)1

Total

1557 (100)

165 (10.6)

 

1138 (100)

91 (8.0)

 

419 (100)

74 (17.7)

 

Role 2

         

Physician

246 (15.8)

17 (6.9)

0.59 (0.27–1.29)

183 (16.1)

10 (5.5)

0.75 (0.27–2.15)

63 (15.0)

7 (11.1)

0.41 (0.11–1.49)

Nurse

705 (45.3)

90 (12.8)

1.47 (0.81–2.80)

478 (42.0)

40 (8.4)

1.81 (0.81–4.55)

227 (54.2)

50 (22.0)

1.24 (0.49–3.38)

Student

69 (4.4)

5 (7.2)

0.75 (0.22–2.20)

64 (5.6)

5 (7.8)

1.05 (0.28–3.59)

5 (1.2)

0 (0.0)

-

Ancillary clinical staff

88 (5.7)

7 (8.0)

0.91 (0.32–2.36)

55 (4.8)

4 (7.3)

1.48 (0.36–5.32)

33 (7.9)

3 (9.1)

0.46 (0.08–2.19)

Administrative

205 (13.2)

23 (11.2)

1.76 (0.86–3.69)

164 (14.4)

18 (11.0)

2.69 (1.10–7.10)

41 (9.8)

5 (12.2)

0.86 (0.21–3.30)

Food/environmental

46 (3.0)

7 (15.2)

4.85 (1.51–14.85)

37 (3.3)

6 (16.2)

8.28 (2.16–31.48)

9 (2.1)

1 (11.1)

1.52 (0.06–17.75)

Other

199 (12.8)

16 (8.0)

0.70 (0.39–1.18)

157 (13.8)

8 (5.1)

0.54 (0.24–1.09)

42 (10.0)

8 (19.0)

1.19 (0.48–2.65)

Location 3

         

COVID ICU

171 (11.0)

26 (15.2)

2.28 (1.29–3.96)

100 (8.8)

10 (10.0)

2.35 (0.97–5.32)

71 (16.9)

16 (22.5)

1.65 (0.71–3.79)

Non-COVID ICU

364 (23.4)

38 (10.4)

0.89 (0.56–1.39)

258 (22.7)

18 (7.0)

0.77 (0.40–1.40)

106 (25.3)

20 (18.9)

1.04 (0.49–2.16)

COVID ward

261 (16.8)

35 (13.4)

1.59 (1.01–2.48)

133 (11.7)

10 (7.5)

1.21 (0.51–2.60)

128 (30.5)

25 (19.5)

1.26 (0.67–2.35)

Non-COVID ward

436 (28.0)

50 (11.5)

1.26 (0.85–1.85)

309 (27.2)

21 (6.8)

0.85 (0.47–1.47)

127 (30.3)

29 (22.8)

2.63 (1.40–4.97)

Labor and delivery

113 (7.3)

4 (3.5)

0.24 (0.06–0.72)

88 (7.7)

4 (4.5)

0.50 (0.12–1.56)

25 (6.0)

0 (0.0)

-

Operating room

196 (12.6)

15 (7.7)

0.99 (0.53–1.78)

173 (15.2)

13 (7.5)

1.13 (0.55–2.17)

23 (5.5)

2 (8.7)

0.76 (0.11–3.43)

Non-operating room procedural

198 (12.7)

16 (8.1)

0.91 (0.49–1.59)

155 (13.6)

14 (9.0)

1.44 (0.72–2.74)

43 (10.3)

2 (4.7)

0.36 (0.05–1.34)

Emergency department

250 (16.1)

20 (8.0)

0.70 (0.40–1.18)

199 (17.5)

13 (6.5)

0.62 (0.31–1.19)

51 (12.2)

7 (13.7)

1.02 (0.36–2.67)

Outpatient clinical unit

188 (12.1)

13 (6.9)

0.70 (0.36–1.27)

143 (12.6)

8 (5.6)

0.72 (0.30–1.53)

45 (10.7)

5 (11.1)

0.63 (0.19–1.73)

Non-clinical unit

249 (16.0)

21 (8.4)

0.70 (0.37–1.24)

201 (17.7)

18 (9.0)

0.76 (0.37–1.51)

48 (11.5)

3 (6.2)

0.47 (0.09–1.76)

Job-related exposures 4

         

Cared for COVID patient

599 (38.5)

69 (11.5)

1.10 (0.79–1.54)

396 (34.8)

29 (7.3)

0.85 (0.52–1.34)

203 (48.4)

40 (19.7)

1.13 (0.67–1.92)

3 + days in contact with COVID patient4

263 (43.9)

35 (13.3)

1.39 (0.83–2.33)

158 (39.9)

19 (12.0)

2.84 (1.27–6.69)

105 (51.7)

16 (15.2)

0.61 (0.29–1.24)

Participated in aerosol-generating procedure4

160 (26.7)

15 (9.4)

0.70 (0.37–1.27)

116 (29.3)

6 (5.2)

0.51 (0.18–1.27)

44 (21.7)

9 (20.5)

1.10 (0.44–2.55)

  1. 1 Adjusted ORs and 95% CI are adjusted for age, gender, race/ethnicity, known COVID-19 exposure at home, role, location, and whether individual cared for a COVID-19 patient
  2. 2 Each role is compared to the entire HCW population, e.g., physicians vs. non-physicians
  3. 3 Individuals may select multiple locations, thus categories are not mutually exclusive. Each aOR corresponds to relative odds of being COVID AB-seropositive for individuals who worked in the specified location versus those who did not
  4. 4 Days in contact with COVID-19 patient and participated in aerosol-generating procedure only applicable for HCWs who reported “yes” to caring for COVID-19 patients
  5. Ab: antibody, HCW: health care worker, CI: confidence interval, rt-PCR: reverse transcriptase polymerase chain reaction, ICU: intensive care unit