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Table 1 Association between demographic and health-related characteristics and SARS-CoV-2 seropositivity of HCW study population and subgroups

From: Risk factors for SARS-CoV-2 seropositivity in a health care worker population during the early pandemic

 

All HCWs (n = 1,557)

Not tested by rt-PCR (n = 1,138)

Tested by rt-PCR (n = 419)

 

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

OR (95% CI)1

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

OR (95% CI)1

HCWs,

n (%)

COVID-19 AB prevalence,

n (%)

OR (95% CI)1

Total

1557 (100)

165 (10.6)

 

1138 (100)

91 (8.0)

 

419 (100)

74 (17.7)

 

Age quartiles (y)

         

18–31

418 (26.8)

49 (11.7)

1.17 (0.82–1.66)

311 (27.3)

33 (10.6)

1.57 (1.00-2.45)

107 (25.5)

16 (15.0)

0.77 (0.41–1.38)

32–38

382 (24.5)

41 (10.7)

1.02 (0.69–1.47)

257 (22.6)

22 (8.6)

1.10 (0.65–1.79)

125 (29.8)

19 (15.2)

0.78 (0.43–1.36)

39–43

377 (24.2)

35 (9.3)

0.83 (0.55–1.21)

275 (24.2)

15 (5.5)

0.60 (0.33–1.03)

102 (24.3)

20 (19.6)

1.19 (0.66–2.07)

49–73

380 (24.4)

40 (10.5)

0.99 (0.67–1.43)

295 (25.9)

21 (7.1)

0.85 (0.50–1.38)

85 (20.3)

19 (22.4)

1.46 (0.80–2.59)

Gender

         

Female

1073 (68.9)

100 (9.3)

0.66 (0.48–0.93)

781 (68.6)

57 (7.3)

0.75 (0.48–1.18)

292 (69.7)

43 (14.7)

0.53 (0.32–0.90)

Male

482 (31.0)

64 (13.3)

1.48 (1.05–2.06)

355 (31.2)

33 (9.3)

1.28 (0.81–1.99)

127 (30.3)

31 (24.4)

1.87 (1.11–3.13)

Other2

2 (0.1)

1 (50.0)

-

2 (0.2)

1 (50.0)

-

0 (0)

-

-

Race/Ethnicity

         

Asian

608 (39.0)

70 (11.5)

1.17 (0.84–1.62)

415 (36.5)

26 (6.3)

0.68 (0.42–1.07)

193 (46.1)

44 (22.8)

1.93 (1.16–3.24)

White

457 (29.4)

46 (10.1)

0.92 (0.64–1.31)

336 (29.5)

32 (9.5)

1.33 (0.84–2.07)

121 (28.9)

14 (11.6)

0.52 (0.27–0.94)

Latino

286 (18.4)

27 (9.4)

0.86 (0.54–1.30)

232 (20.4)

18 (7.8)

0.96 (0.55–1.61)

54 (12.9)

9 (16.7)

0.92 (0.41–1.90)

Black

29 (1.9)

3 (10.3)

0.97 (0.23–2.80)

25 (2.2)

2 (8.0)

1.00 (0.16–3.46)

4 (1.0)

1 (25.0)

1.56 (0.08–12.39)

Mixed/Other/Not reported

177 (11.4)

19 (10.7)

1.02 (0.60–1.65)

130 (11.4)

13 (10.0)

1.32 (0.68–2.38)

47 (11.2)

6 (12.8)

0.65 (0.24–1.50)

Comorbidities

         

Any comorbidities

370 (23.8)

41 (11.1)

1.07 (0.73–1.54)

258 (22.7)

18 (7.0)

0.83 (0.47–1.39)

112 (26.7)

23 (20.5)

1.30 (0.74–2.22)

Asthma or COPD

155 (10.0)

16 (10.3)

0.97 (0.54–1.62)

114 (10.0)

9 (7.9)

0.98 (0.45–1.92)

41 (9.8)

7 (17.1)

0.96 (0.38–2.13)

Diabetes mellitus

67 (4.3)

10 (14.9)

1.51 (0.71–2.89)

45 (4.0)

3 (6.7)

0.82 (0.19–2.30)

22 (5.3)

7 (31.8)

2.30 (0.85–5.68)

Hypertension

172 (11.0)

18 (10.5)

0.98 (0.57–1.61)

118 (10.4)

5 (4.2)

0.48 (0.17–1.10)

54 (12.9)

13 (24.1)

1.58 (0.77–3.06)

Smoking or vaping

37 (2.4)

4 (10.8)

1.02 (0.30–2.61)

24 (2.1)

2 (8.3)

1.05 (0.17–3.63)

13 (3.1)

2 (15.4)

0.84 (0.13–3.23)

COVID-19 exposure outside of work

58 (3.7)

12 (20.7)

2.29 (1.14–4.29)

28 (2.5)

5 (17.9)

2.59 (0.85–6.47)

30 (7.2)

7 (23.3)

1.46 (0.56–3.39)

  1. 1 Odds ratios (OR) are unadjusted, comparing the selected group to the entire HCW population
  2. 2 OR for Other gender omitted due to small sample size (n < 5)
  3. Ab: antibody, HCW: health care worker, CI: confidence interval, rt-PCR: reverse transcriptase polymerase chain reaction, COPD: chronic obstructive pulmonary disease
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BMC Infectious Diseases

ISSN: 1471-2334

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