Table 1 Characteristics of the thirteen patients with T. whipplei infection in China
From: Whipple’s disease presenting as weight gain and constipation in a Chinese woman
Year | Age/sex | Presentation | Organ involvement | Diagnosis method | Comorbidities | Treatment | Outcome |
|---|---|---|---|---|---|---|---|
2007 [4] | 30/M | Transient loss of consciousness, hypologia, alexia | Brain | PAS(+) PCR | Nil | Amoxicillin, and chloromycin | Nil |
2017 [5] | Case 1: 54/F | Nil | Mitral valve | PAS(+) PCR | Nil | Nil | Nil |
Case 2: 64/F | Nil | Left atrium, mitral valve | PAS(+) PCR | Nil | Nil | Nil | |
2021 [6] | Case 1: 39/F | Cough, shortness of breath, fever | Lung | mNGS of BAL | Nil | Sulfamethoxazole, meropenem and fluconazole for 17 days | Recovered |
Case 2: 81/M | Cough, shortness of breath | Lung | mNGS of BAL | Nil | Sulfamethoxazole, voriconazole and methylprednisolone for 5 days | Death | |
2021 [7] | 23/F | Respiratory distress, shortness of breath, fever, weight loss, joint pain | Lung | mNGS of BAL | Nil | Imipenem, fluconazole, polymyxin B for 18 days (For treatment of carbapenem-resistant Acinetobacter baumannii pneumonia) | Recovered |
2021 [8] | 28/M | Dry cough, shortness of breath | Lung | mNGS of BAL | AIDS | Sulfamethoxazole-trimethoprim (For treatment of Pneumocystis jirovecii infection), Meropenem, caspofungin, methylprednisolone for 16 days | Recovered |
2021 [9] | 44/M | Dry cough, shortness of breath | Lung | mNGS of BAL | DM, HCV infection | Trimethoprim/sulfamethoxazole, isoniazid, rifapentine, amikacin, ethambutol (For treatment of Mycobacterium tuberculosis) | Recovered |
2021 [10] | Case 1: 64/M | Cough and dyspnea | Lung | Nanopore of BAL | DM, Interstitial lung disease | Streptomycin and penicillin G for 2 weeks, then trimethoprim/sulfamethoxazole | Recovered |
Case 2: 31/M | Fever, cough, intermittent diarrhea, weight loss, and arthralgia | Lung | Nanopore of BAL | Dermatomyositis, Interstitial lung disease | Voriconazole, levofloxacin, ganciclovir, sulfamethoxazole (duration not mentioned) | Recovered | |
Case 3: 59/M | Dry cough | Lung | Nanopore of BAL | Interstitial lung disease | None | Nil | |
2021 [11] | 26/M | Left chest pain | Lung | mNGS of BAL | Nil | Ceftriaxone for 2 weeks, then trimethoprim/sulfamethoxazole (duration not mentioned) | Recovered |
2022 [12] | 62/M | Multiple subcutaneous nodules | Skin | PAS(+) PCR | Nil | Doxycycline, and hydroxychloroquine for 1 year | Recovered |