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Table 1 Doses and usage of study drugs by body weight

From: Optimizing (O) rifapentine-based (RI) regimen and shortening (EN) the treatment of drug-susceptible tuberculosis (T) (ORIENT) using an adaptive seamless design: study protocol of a multicenter randomized controlled trial

  1. All drugs will be administered orally
  2. Rifampicin, isoniazid and pyrazinamide are given once a day before breakfast
  3. Moxifloxacin and rifapentine should be administered together once daily with food
  4. Ethambutol should be taken by body weight 750 to 1000 mg/d, divided into 1 to 3 times, before or after meals