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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Optimizing (O) rifapentine-based (RI) regimen and shortening (EN) the treatment of drug-susceptible tuberculosis (T) (ORIENT) using an adaptive seamless design: study protocol of a multicenter randomized controlled trial

Fig. 1

ORIENT study schematic. The trial plans to recruit DS-TB patients susceptible to rifampicin, isoniazid, pyrazinamide, ethambutol, and fluoroquinolones. Participants will be randomly divided into different arms as shown in the figure. Abbreviations in this figure: DS-TB: drug-susceptible tuberculosis. 8wHRZE/18wHR: rifampicin (R), isoniazid (H), pyrazinamide (Z), and ethambutol (E) for 8-week intensive phase and rifampicin and isoniazid for 18-week continuous phase. 8wHPZM/9wHPM: rifapentine (P), isoniazid(H), pyrazinamide (Z), and moxifloxacin (M) for 8-week intensive phase and rifapentine, isoniazid and moxifloxacin for 9-week continuous phase. 8wHPZM/18wHPM: rifapentine (P), isoniazid (H), pyrazinamide (Z), and moxifloxacin (M) for 8-week intensive phase and rifapentine, isoniazid and moxifloxacin for 18-week continuous phase

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BMC Infectious Diseases

ISSN: 1471-2334

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