Table 3 Main findings of the included studies
Author, year, journal | Intervention evaluated | Number of intervention patients | CRP cut-off | CRP test and method | Comparator |
|---|---|---|---|---|---|
Oliveira, C. F. et al., 2013, Crit Care Med | CRP-guided discontinuation of antibiotic therapy in patients with sepsis or septic shock. *Patients with a SOFA score > 10 and a positive blood culture result received at least 7 days of antibiotic therapy | 45 | - CRP < 25 mg/L (if initial CRP < 100 mg/L) or 7 days of antibiotic therapy- Decrease ≥ 50% (if initial CRP ≥ 100 mg/L) or 7 days of antibiotic therapy | Reactive test VITROS (Johnson & Johnson Clinical Diagnostics, Inc., Rochester, NY) | Discontinuation of antibiotic therapy guided by procalcitonin serum levels in patients with sepsis or septic shock considering initial clinical status and the SOFA score. **Patients with a SOFA score > 10 and a positive blood culture result received at least 7 days of antibiotic therapy |
Borges, I. et al., 2020, Crit Care Med | Duration of antibiotic therapy guided by daily monitoring of CRP serum levels in critically ill infected adult patients | 64 | - CRP < 35 mg/L (if initial CRP < 100 mg/L)—CRP decrease ≥ 50% (if initial CRP ≥ 100 mg/L) | Test for the quantitative determination of serum CRP concentration (Vitros-Johnson & Johnson, USA) | Best practices for rational use of antibiotics according to the best evidence established in the literature for duration of antibiotic treatment, microbiological data, and estimated previous time regarding the infectious site |
von Dach, E. et al., 2020, JAMA | CRP-guided antibiotic treatment duration in adults hospitalized with gram-negative bacteremia | 170 | Once serum CRP had decreased to 75% from its peak and if fever was absent for at least 48 h. OR At 14-day of treatment (if by day 14 the CRP level had not decreased to 75% of its maximum value, it was no longer used to guide therapy) | CRP was measured via immunoturbidimetry (more details about the method were not provided) | The CRP group was compared to two fixed-length antibiotic therapy groups (7 and 14 days). Local guidelines oriented antibiotics choice, including changes in the route of administration when appropriate |