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Table 2 In vitro antifungal susceptibility testing of 203 clinical isolates into 5 antifungal agents

From: Epidemiology, antifungal susceptibility, risk factors, and mortality of persistent candidemia in adult patients in China: a 6-year multicenter retrospective study

Species

(No of isolates)

Antifungal agent

Resistant n(%)

Non- PC(167)

PC(36)

total

Pc

C. albicans (77)

Amphotericin B

0

0

0b

-

 

Flucytosine

1(1.4)

0

1(1.3)b

0.791

 

Fluconazole

9(12.5)

2(40.0)

11(14.3)

0.089

 

Itraconazole

15(20.8)

2(40.0)

17(22.1)b

0.318

 

Voriconazole

13(18.1)

1(20.0)

14(18.2)b

0.913

 C. glabrata (40)

Amphotericin B

0

0

0b

0.078

 

Flucytosine

0

0

0b

-

 

Fluconazole

2(5.9)

0

2(5.0)

0.542

 

Itraconazole

4(11.8)

0

4(10.0)b

0.376

 

Voriconazole

0

0

0b

-

C.tropicalis (41)

Amphotericin B

1(2.9)

0

1(2.4)b

0.646

 

Flucytosine

0

0

0b

-

 

Fluconazole

12(35.3)

3(42.9)

15(36.6)b

0.705

 

Itraconazole

12(35.3)

3(42.9)

15(36.6)b

0.705

 

Voriconazole

13(38.2)

3(42.9)

16(39.0)b

0.819

 C. parapsilosis (33)

Amphotericin B

0

0

0

-

 

Flucytosine

0

0

0

-

 

Fluconazole

0

0

0

-

 

Itraconazole

0

0

0

-

 

Voriconazole

0

0

0

-

C. krusei (5)

Amphotericin B

0

0

0

-

 

Flucytosine

1(50.0)

0

1(20.0)b

0.171

 

Fluconazolea

-

-

-

 
 

Itraconazole

0

2(66.7)

2(40.0)b

0.136

 

Voriconazole

0

1(33.3)

1(20.0)b

0.361

Others*(7)

Amphotericin B

0

0

0

-

 

Flucytosine

0

0

0

-

 

Fluconazole

0

0

0

-

 

Itraconazole

0

0

0

-

 

Voriconazole

0

0

0

-

All of isolates (204)

Amphotericin B

1(0.6)

0

1(0.5)

0.642

 

Flucytosine

2(1.2)

0

2(1.0)

0.509

 

Fluconazolea

23(13.9)

5(15.2)

28(14.1)

0.285

 

Itraconazole

31(18.5)

7(19.4)

38(18.6)

0.902

 

Voriconazole

26(15.5)

5(13.9)

31(15.2)

0.799

  1. MIC: minimal inhibitory concentration, PC: persistent candidemia
  2. aResistance rate was based on the intrinsic resistance of C. krusei and did not follow the actual MICs.
  3. bThe breakpoints of Candida spp. according to the manufacturer’s instructions for the ATB FUNGUS 3 system
  4. cThe difference in resistance rate between non-PC and PC was analyzed by chi-square test
  5. *Others include C. guilliermondii (2), C. famata (2), C. dubliniensis (1), C. haemulonii (1) and C. inconspicua (1)