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Table 2 Risk factors associated with in-hospital detection of VRE in primary and secondary analysis in logistic regression analyses

From: Previous antibiotic therapy as independent risk factor for the presence of vancomycin-resistant enterococci in surgical inpatients. Results from a matched case-control study

risk factor

cases

controls

uni-variate1

multi-variate,2

   

OR3 (95% CI3)

p-value

OR (95% CI)

p-value

LOS3 hospital, median (IQR)

15 (9–28)

7 (3, 12)

1.054 (1.028–1.081)

p ≤ 0.0001

  

LOS ICU3, median (IQR)

4 (1-10.5)

1 (0, 2)

1.114 (1.056–1.175)

p ≤ 0.0001

  

dialysis, n (%)

28 (24.1)

8 (6.9)

4.295 (1.864–9.897)

p ≤ 0.0005

3.309 (1.387–7.897)

p ≤ 0.0082

CVC3, n (%)

104 (89.7)

89 (76.7)

2.629 (1.259–5.492)

p ≤ 0.0167

1.663 (0.769–3.597)

p ≤ 0.3443

endoscopy, n (%)

55 (47.4)

34 (29.3)

1.802 (1.014–3.202)

p ≤ 0.0065

1.403 (0.761–2.585)

p ≤ 0.0821

sonography, n (%)

90 (77.6)

64 (55.2)

2.812 (1.591–4.971)

p ≤ 0.0009

2.169 (1.194–3.940)

p ≤ 0.0145

radiology (X-ray, CT, MRT), n (%)

102 (12.1)

78 (67.2)

3.549 (1.798–7.006)

p ≤ 0.0004

2.327 (1.136–4.769)

p ≤ 0.0623

antibiotics DOT, median (IQR)

16 (10–28)

4 (2, 11.5)

1.082 (1.052–1.112)

p ≤ 0.0001

1.069 (1.037–1.102)

p ≤ 0.0001

 

mean (IQR)

OR (95% CI)

p-value

P/T3 DOT

4.7 (0-7.5)

2.2 (0–2)

1.139 (1.067–1.216)

0.0001

1.116 (1.043–1.195)

0.0006

 A/S3 DOT

0.7 (0–0)

0.2 (0–0)

1.131(0.962–1.329)

0.1465

1.132 (0.945–1.356)

0.2069

meropenem DOT

3.9 (0-7.5)

0.8 (0–0)

1.198 (1.103–1.301)

0.0001

1.154 (1.058–1.258)

0.0005

imipenem DOT

0.3 (0–0)

0.3 (0–0)

1.013 (0.879–1.169)

0,6406

0.940 (0.810–1.093)

0.4870

CEPH3 2nd gen DOT

0.8 (0–1)

1.1 (0–1)

0.926 (0.798–1.074)

0.0047

0.953 (0.822–1.104)

0.4427

CEPH3 3rd gen DOT

0.7 (0–0)

0.4 (0–0)

1.067 (0.923–1.233)

0.1793

1.069 (0.921–1.241)

0.3129

ciprofloxacin DOT

2.1 (0–2)

0.7 (0–0)

1.147 (1.039–1.268)

0.0022

1.114 (1.002–1.238)

0.0502

levofloxacin DOT

0.2 (0–0)

0.2 (0–0)

1.040 (0.813–1.329)

0,8359

0.931 (0.697–1.245)

0.6474

metronidazole DOT

2.1 (0–3)

1.6 (0-1.5)

1.052(0.967–1.144)

0.5788

1.063 (0.975–1.160)

0.1267

vancomycin DOT

2.7 (0–3)

0.5 (0–0)

1.215(1.097–1.346)

0.0001

1.150(1.036–1.276)

0.0031

macrolids DOT

0.9(0–0)

0.3(0–0)

1.234(1.031–1.476)

0.0099

1.152(0.957–1.387)

0.0872

tetracyclins DOT

0.1(0–0)

0 (0–0)

1.121 (0.769–1.635)

1.0000

1.058(0.723–1.547)

0.7044

aminoglycosides DOT

0.1 (0–0)

0 (0–0)

nd4

0.2500

nd4

0.5270

linezolid DOT

0.3 (0–0)

0.3 (0–0)

1.010 (0.881–1.158)

0.9063

0.980(0.848–1.132)

0.8598

rifampicin DOT

0.1(0–0)

0.2 (0–0)

0.951 (0.792–1.141)

1.0000

0.912 (0.764–1.089)

0.3286

nitrofurantoin DOT

0 (0–0)

0 (0–0)

nd4

1.0000

nd4

0.1897

T/S3 DOT

0.2 (0–0)

0.1 (0–0)

0.981(0.848–1.135)

0.2813

0.919 (0.783–1.079)

0.3385

clindamycin DOT

0.1 (0–0)

0.3 (0–0)

1.107 (0.863–1.420)

0.3672

1.097 (0.844–1.427)

0.4649

  1. 1unadjusted p-values (without Bonferroni correction), bold type indicates significant values with p < 0.05
  2. 2unadjusted p-values (without Bonferroni correction), multivariate analysis of matched pairs with length of stay in hospital as confounder, bold type indicates significant values after Bonferroni correction
  3. 3 A/S, ampicillin/sulbactam; CEPH, cephalosporin; CI, confidence interval; CVC, central venous catheter; DOT, days of antibiotic therapy; IQR, inter quartil range between the 25% and 75% quartils; LOS, length of stay; OR, odds ratio; P/T, piperacillin/tazobactam; T/S, trimethoprim/sulfamethoxazole
  4. 4OR and CI not defined because the antibiotic was not used in the control group